Results 151 to 160 of about 36,927 (297)

β2-AR signaling in MDSCs [PDF]

Nature Immunology, 2019
openaire   +2 more sources

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

HIGH MOBILITY GROUP BOX 1 (HMGB1) ENHANCES IMMUNE SUPPRESSION BY REGULATING MYELOID-DERIVED SUPPRESSOR CELL (MDSC) DIFFERENTIATION, FUNCTION, AND SURVIVAL

, 2015
Chronic inflammation is associated with malignant transformation and tumor progression. The immune system also plays a role in tumor progression, with tumor immune escape recognized as a hallmark of cancer. During tumor immune escape, tumor cells produce
Parker, Katherine
core   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Correlation of myeloid derived suppressor cell (MDSC) populations with clinicopathologic features in urothelial carcinoma (UC).

, 2016
434 Background: MDSC are a heterogeneous population of potent immunosuppressive cells with potential predictive/prognostic significance in solid tumors.
Marcelo Lamenza, Pam Profusek, Allison Janine Tyler, Steven C. Campbell, Andrew J. Stephenson, Amr Farouk Fergany, Jorge A. Garcia, Hamid Emamekhoo, Petros Grivas, Pat A. Rayman, Brian I. Rini, Marc S. Ernstoff, James Finke, Paul Elson, Sylvia Stybor, C. Marcela Diaz-Montero, Samuel Haywood, Moshe Chaim Ornstein, Kim Schach   +18 more
core   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Adoptive transfer of BM-derived MDSC does not prevent the development of autoimmune diabetes.

, 2014
Type 1 diabetes was induced in RIP-mOVA mice by injecting (i.v.) naive CD8+ T cells from OT-1 TCR-transgenic mice together with an anti-OVA polyclonal antibody (i.p.). Blood glycemia was monitored every day during at least 12 days.
Marcelo Hill (199047), Laura Carretero-Iglesia (577929), Maria Cristina Cuturi (199079), Gaelle Beriou (5659441), Emmanuel Merieau (577931), Yves Delneste (132672), Cedric Louvet (577932), Lucile Drujont (577928), Laurence Bouchet-Delbos (577930)   +8 more
core   +1 more source

Synthesis and characterization of polymer networks obtained by conventional radical and RAFT copolymerization processes in supercritical carbon dioxide

The Canadian Journal of Chemical Engineering, EarlyView.
Conventional and RAFT dispersion copolymerizations of HEMA and EGDMA in supercritical CO2 are compared in terms of swelling index (crosslink density), morphology, particle size distribution, and modular differential scanning calorimetry. Abstract The syntheses of net‐poly((2‐hydroxyethylene methacrylate)‐co‐(ethylene glycol dimethacrylate ...
Patricia Pérez‐Salinas, Karen Mozeltzin Gómez‐Cruz, Alberto Rosas‐Aburto, Maribel Pineda‐Herrera, Humberto Vázquez‐Torres, Graeme Moad, Eduardo Vivaldo‐Lima   +6 more
wiley   +1 more source

In vitro differentiation of MDSC-like cells as a model for studying immunosuppressive mechanisms in pediatric B cell lymphoma.

reservedDiffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that is rarely manifested in pediatric patients, and research into the immunoregulatory environment present in the disease is limited due to the scarcity of patient samples ...
SABYR, INKAR
core