Results 141 to 150 of about 36,927 (297)

Supplementary Figures 1 through 11 from MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation

, 2016
Supplemental Figure 1. MIF-inhibitor treatment does not alter the viability of melanoma MDSCs or A375 melanoma cell line and melanoma patient-derived MDSCs show increased levels of reactive oxygen species (ROS). Supplemental Figure 2. Characterization of
Beatriz E. Rendon (14887769), Eun Jung Kim (783746), Kavitha Yaddanapudi (147127), Sabrin Albeituni (10699242), Sabine Waigel (129778), Gwyneth Lamont (15114814), Numan Al Rayyan (15114817), Robert A. Mitchell (8532171), Ashley Wise (15114823), Jamaal Richie (15114820)   +9 more
core   +1 more source

pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

Allojenik kemik iliği nakli yapılan hastalarda kimerizm, (MDSC) ve sağkalım ile miyeloid kökenli baskılayıcı hücreler (mdsc) arasındaki ilişkinin araştırılması

, 2019
Miyeloid kökenli baskılayıcı hücreler (MDSC), myeloid hücrelerin tam olarak tanımlanmış bir alt grubu olmaktan ziyade matür hücrelere farklılaşmaları engellenmiş aktive immatür hücrelerin oluşturduğu, monosit ve granülosit alt kümeleri içeren heterojen ...
BURÇİN ERDEM KINAŞ
core  

Abstract 1922: Do stress response genes play a role in maintaining MDSC survival and suppression

, 2010
Myeloid- derived suppressor cells (MDSC) contribute to immune suppression in tumor bearing individuals. Their suppression and survival are increased by inflammation.
Daniel W. Beury, Minu K. Srivastava, Suzanne Ostrand-Rosenberg, Phillip Fitzgerald   +3 more
core   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Myeloid derived suppressor cells (MDSC): characterization and expansion in models of endotoxemia and transplantation

, 2011
CD11b+GR1+ myeloid-derived suppressor cells (MDSC) accumulate in several inflammatory conditions including cancer, infections, or trauma. MDSCs are found in bone marrow and lymphoid organs and suppress both innate and adaptive immune responses.
Van Rompaey, Nicolas, Le Moine, Alain
core  

KIRA6 restrains the generation of myeloid-derived suppressor cells and overcomes resistance to anti-PD-1 therapy

Cell Death and Disease
Immune checkpoint blockade (ICB) therapy is one of the cornerstones of cancer treatment regimens, but the overall response rates remain low because of suppressive immune cells, such as myeloid-derived suppressor cells (MDSC).
Chun Chen, Jing Chen, Xiaowen Lin, Jiali Hu, Yuncong Zhang, Dingjie Liu, Xumei Ouyang, Jing Li, Wenting Li, Shiying Xie, Ya Meng, Meixiao Zhan, Yongjun Peng, Hong-Wei Sun   +13 more
doaj   +1 more source

Myeloid-derived suppressor cells in axial spondyloarthritis patients with different types of therapy

Научно-практическая ревматология
Aim – to evaluate myeloid-derived suppressor cell (MDSC) subset counts and their suppressor potential in axial spondyloarthritis (axSpA) patients, as well as to analyze changes in the studied parameters in biological therapy (BT).Materials and methods ...
A. Yu. Morenkova, T. V. Tyrinova, A. V. Fedorova, M. A. Tikhonova, N. A. Ilina, O. A. Chumasova, A. E. Sizikov, E. R. Chernykh   +7 more
doaj   +1 more source

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source