Results 121 to 130 of about 36,927 (297)

Accumulation of MDSC subsets in renal cell carcinoma correlates with grade and progression free survival, and is associated with intratumoral expression of IL-1β, IL-8 and CXCL5 [PDF]

, 2014
Myeloid derived suppressor cells (MDSC, CD33+CD11b+ HLA-DR low/-) play a major role in tumor-mediated immune evasion and are composed of at least 3 subsets PMN (CD15+), monocytic (CD14+) and lineage-negative (CD15-CD14-), and each has been shown to be ...
Najjar, Yana G, Finke, James, Jia, Xuefei, Hamilton, Tom, Rini, Brian, Tannenbaum, Charlie, Elson, Paul, Rayman, Patricia A, Diaz-Montero, C Marcela, Yana G Najjar, Charlie Tannenbaum, Xuefei Jia, Brian Rini, Patricia A Rayman, James Finke, Paul Elson, C Diaz-Montero, Tom Hamilton   +17 more
core   +1 more source

SP and TP are comparable in evaluating PMN-MDSC frequency in ex vivo PBMC.

, 2018
A. Gating strategy used to identify PMN-MDSC in ex vivo PBMC using SP and TP protocols: after doublets exclusion (FSC-A/FSC-H), in the morphological gate (FSC/SSC) we excluded debris, then we gated Lin-/HLA DRlow/- cells.
Eleonora Cimini (322110), Chiara Agrati (322137), Alessandra Sacchi (322123), Veronica Bordoni (296203), Adriana Ammassari (316143), Rita Casetti (608635), Nicola Tumino (650284), Andrea Antinori (103654), Germana Grassi (3366716)   +8 more
core   +1 more source

Diagnostic profiling of MDSCs in sepsis [PDF]

, 2021
With 50 million cases and 11 million deaths per year, sepsis is one of the leading causes of death worldwide. Sepsis is caused by a dysregulated host response to an infection, which consists of concurrent inflammatory and immunosuppressive reactions.
openaire  

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Effect of neonatal G-MDSC on T cell proliferation.

, 2014
(A) Proliferative responses of purified T cells in the presence or absence of G-MDSC after anti-CD3/CD28 bead stimulation (n = 28 independent experiments performed in duplicate for CD3 plots, n = 6 for CD4 and CD8 plots).
Helen Horton (10466), Nicholas Lejarcegui (425026), Ana Gervassi (632929), Grace Itaya (632931), Heather Jaspan (632934), Sandra Dross (632930), Amanda Jacobson (425024), Soren Gantt (632933), Elvis Kidzeru (632932)   +8 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Granulocytic Myeloid-Derived Suppressor Cells in Breast Milk (BM-MDSC) Correlate with Gestational Age and Postnatal Age and Are Influenced by Infant’s Sex

, 2020
Background: Infections are the main cause of death in preterm infants. Causative agents often descend from the intestinal flora of the infected neonate, indicating insufficient protection by the mucosal barrier.
Natascha Köstlin-Gille, Marco Ginzel, Lara-Antonia Flaig, Christian F. Poets, Christian Gille, Jörg Arand   +5 more
core   +1 more source

Increased circulating polymorphonuclear myeloid-derived suppressor cells are associated with prognosis of metastatic castration-resistant prostate cancer

Frontiers in Immunology
IntroductionMyeloid-derived suppressor cell (MDSC) exhibits immunosuppressive functions and affects cancer progression, but its relationship with prostate cancer remains unclear.
Takuro Kobayashi, Takuro Kobayashi, Masayoshi Nagata, Tsuyoshi Hachiya, Haruhiko Wakita, Yoshihiro Ikehata, Yoshihiro Ikehata, Keiji Takahashi, Toshiyuki China, Fumitaka Shimizu, Jun Lu, Yiming Jin, Yan Lu, Hisamitsu Ide, Shigeo Horie, Shigeo Horie   +15 more
doaj   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Expansion of MDSC in peripheral blood and splenocytes from TB mice.

, 2013
(A) MDSC percentages in peripheral blood (PB) from TB and control mice. Shown are representative flow cytometry results of Mac-1+Gr-1+ MDSC. (B) Represented is the Mean ± S.E.M of the relative percentages of MDSC in TB and control mice.
Maya Jerald (338888), Nadine Nelson (338885), Nasreen Vohra (338886), Laura Pendleton (338890), Shari Pilon-Thomas (338884), Karoly Szekeres (338891), Tomar Ghansah (338893)   +6 more
core   +1 more source