Results 101 to 110 of about 36,927 (297)

Purity of educated G-MDSC after magnetic cell separation.

, 2016
It is well known that mesenchymal stem cells (MSC) have a role in promotion of tumor growth, survival and drug-resistance in chronic myeloid leukemia (CML).
Paolo Vigneri (230304), Annalisa Chiarenza (596875), Daniele Tibullo (596872), Nunziatina Laura Parrinello (3156843), Giuseppe Alberto Palumbo (3156846), Fabio Stagno (596878), Cesarina Giallongo (596870), Maria Violetta Brundo (618086), Vincenzo Bramanti (2501365), Alessandra Romano (596874), Piera La Cava (596873), Francesco Di Raimondo (207787), Chiarenza A., Tibullo D., Romano A., Bramanti V., Vigneri P., Giallongo C., Di Raimondo F., Palumbo G. A., Brundo M. V., Stagno F., La Cava P., Parrinello N. L., La Cava P, Giallongo C, Tibullo D, Parrinello NL, VIGNERI, PAOLO, Chiarenza A, BRUNDO, MARIA VIOLETTA, Palumbo GA, Romano A, DI RAIMONDO, FRANCESCO, Stagno F, Bramanti V   +35 more
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

The Immunosuppressive Activity of MDSCs Requires Expression of CHOP [PDF]

Cancer Discovery, 2014
Abstract The stress sensor CHOP enhances the accumulation and inhibitory activity of MDSCs in tumors.
openaire   +2 more sources

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Effect of in vivo MDSC transplantation and NMES on CD31 positive cells in dystrophic muscles.

, 2013
(A) Fold change in CD31+ cells on MDSC, PBS+NMES and MDSC+NMES groups, when compared to PBS injected controls (n = 5–6/group). (B) CD31 immunostaining in the tissue cross-sections of TA muscles across experimental groups (20× magnification).
Johnny Huard (192304), Bridget M. Deasy (391427), Fabrisia Ambrosio (391429), Giovanna Distefano (391424), G. Kelley Fitzgerald (391428), Christopher Weiss (391426), Michael L. Boninger (279871), Ricardo Jose Ferrari (391425)   +7 more
core   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Main results for meta-analysis between MDSC and clinicopathological factors.

, 2019
Main results for meta-analysis between MDSC and clinicopathological factors.
Xinyu Zhang (14029), Tianyu Li (479460), Xin Fu (448766), Huimin Yan (281436)   +3 more
core   +1 more source

Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery

Journal of Translational Medicine, 2018
Background Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by inducing myeloid-derived suppressor ...
Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang, Jun Wang   +6 more
doaj   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source