Results 81 to 90 of about 43,753 (301)
Frontiers in Immunology, 2018 The treatment of autoimmune diseases still poses a major challenge, frequently relying on non-specific immunosuppressive drugs. Current efforts aim at reestablishing self tolerance using immune cells with suppressive activity like the regulatory T cells (
Margot Zöller +6 more
doaj +1 more source
Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage. [PDF]
PLoS ONE, 2014 Subcutaneous tumors induce the accumulation of myeloid derived suppressor cells (MDSC) not only in blood and spleens, but also in livers of these animals.
Tobias Eggert +5 more
doaj +1 more source
Annals of Medicine, 2022 Background Myeloid-derived suppressor cell (MDSC) mobilisation is an important immune event in acute myocardial infarction (AMI). The A2B adenosine receptor (A2BAR) plays key role in regulating MDSC function, but its specific involvement in MDSC ...
Zongying Yu +5 more
doaj +1 more source
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]
, 2019 Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel +4 more
core +1 more source
Advanced Science, EarlyView.Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang +10 more
wiley +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources
Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
The Role of Myeloid Derived Suppressor Cells in Urothelial Carcinoma Immunotherapy
Bladder Cancer, 2019 Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. In patients with cancer, MDSC are associated with adverse oncologic outcomes and therapeutic resistance.
Kathleen Puttmann +5 more
doaj +1 more source
Evolution of structural ({\alpha}) relaxation-time anomalies in GexSe1-x Chalcogenide glasses
, 2015 We examine enthalpy relaxation across the chalcogenide glass series GexSe1-x, prepared over close-by compositions using conventional melt-quenching technique. We estimate the timescale {\tau}(Tg) characterizing enthalpic relaxation near the kinetic glass
Awasthi, A. M. +2 more
core +1 more source
Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]
, 2017 Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong +2 more
core +2 more sources