Results 91 to 100 of about 43,753 (301)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Myeloid Derived Suppressor Cells Expansion Persists After Early ART and May Affect CD4 T Cell Recovery

Frontiers in Immunology, 2019
Myeloid-derived suppressor cells (MDSC) are expanded during HIV-1 infection and correlated with disease progression. MDSC expand in the early phase of primary infection depending on TRAIL level.
Chiara Agrati, Nicola Tumino, Veronica Bordoni, Carmela Pinnetti, Andrea Sabatini, Alessandra Amendola, Isabella Abbate, Patrizia Lorenzini, Annalisa Mondi, Rita Casetti, Eleonora Cimini, Germana Grassi, Andrea Antinori, Alessandra Sacchi   +13 more
doaj   +1 more source

Comment on "microscopic theory of network glasses"

, 2003
Calorimetric experiments on network glasses provide information on the ergodicity (landscape) temperature of supercooled liquids and can be compared with a recent theory developed by Hall and Wolynes [PRL90, 085505 (2003)]Comment: 2 pages, 2 EPS figures ...
C. A. Angell, M. Micoulaut, P. Boolchand, P. Boolchand   +3 more
core   +1 more source

Changes induced by UV radiation in the presence of sodium benzoate in films formulated with polyvinyl alcohol and carboxymethyl cellulose [PDF]

, 2015
This work was focused on: i) developing single and blend films based on carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVOH) studying their properties, ii) analyzing the interactions between CMC and PVOH and their modifications UV-induced in the ...
Giannuzzi, Leda, Pinotti, Adriana Noemi, Rivero, Sandra G. M., Villarruel, S.   +3 more
core   +2 more sources

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Melt homogenization and self-organization of chalcogenides glasses: evidence of sharp rigidity, stress and nanoscale phase separation transitions in the GexSe100-x binary

, 2011
A Raman profiling method is used to monitor growth of GexSe100-x melts and reveals a two step process of homogenization. Resulting homogeneous glasses show the non-reversing enthalpy at Tg, {\Delta}Hnr(x), to show a square-well like variation with x ...
Anderson, Angell, Azoulay, Barre, Bauchy, Bhosle, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Bresser, Bridenbaugh, Brière, Chakravarty, Chen, Chen, Chen, Chubynsky, Feltz, Feng, Franzblau, Georgiev, Gjersing, Guin, He, Jackson, Jacobs, Kauzmann, Kibalchenko, Madhu, Mahadevan, Massobrio, Mauro, Micoulaut, Micoulaut, Micoulaut, Micoulaut, Micoulaut, Micoulaut, Murase, Novita, Petri, Phillips, Qu, Richet, Salmon, Selvanathan, Senapati, Sharma, Sreeram, Stolen, Thomas, Thorpe, Wang, Wang, Yonezawa   +59 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function [PDF]

, 2010
Background: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g.
Aerts, J.G.J.V. (Joachim), Hegmans, J.P.J.J. (Joost), Hendriks, R.W. (Rudi), Hoogsteden, H.C. (Henk), Lambers, M.E.H. (Margaretha), Nimwegen, M. (Menno) van, Veltman, J.D. (Joris)   +6 more
core   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells

Frontiers in Cellular and Infection Microbiology, 2018
Staphylococcus aureus is one of the major human bacterial pathogens causing a broad spectrum of serious infections. Myeloid-derived suppressor cells (MDSC) represent an innate immune cell subset capable of regulating host-pathogen interactions, yet their
Hartmut Stoll, Michael Ost, Anurag Singh, Roman Mehling, Davide Neri, Iris Schäfer, Ana Velic, Boris Macek, Dorothee Kretschmer, Christopher Weidenmaier, Andreas Hector, Rupert Handgretinger, Friedrich Götz, Andreas Peschel, Andreas Peschel, Dominik Hartl, Dominik Hartl, Nikolaus Rieber, Nikolaus Rieber, Nikolaus Rieber   +19 more
doaj   +1 more source