Results 91 to 100 of about 36,927 (297)

INTERROGATING PROTEIN CARGOES OF MDSC-DERIVED EXOSOMES ON THE BASIS OF POST-TRANSLATIONAL MODIFICATIONS [PDF]

, 2017
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells which accumulate in cancer patients and tumor-bearing mice. Their function in the tumor microenvironment is to inactivate the immune response to cancer by suppressing both the adaptive ...
Chauhan, Sitara
core   +1 more source

Chemoimmunomodulation of MDSCs as a novel strategy for cancer therapy [PDF]

OncoImmunology, 2012
Tumor-induced myeloid-derived suppressor cells (MDSCs) are a critical barrier to effective immunotherapy of cancer. We identified that Docetaxel and a natural compound, Icariin, can target MDSCs with preferential apoptosis of M2 cells and polarization of the surviving cells towards M1 cells.
Julie, Djeu, Sheng, Wei
openaire   +2 more sources

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice

, 2022
Background Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer.
Verena Müller, Peter Altevogt, Feyza Özbay Kurt, Samantha Lasser, Alina Siebenmorgen, Carolina De La Torre, Alisa Lepper, Rebekka Bitsch, Jochen Utikal, Viktor Umansky, Annina Kurzay   +10 more
core   +1 more source

Frequencies of Circulating Immune Cells in Patients with Parkinson’s Disease: Correlation with MDS-UPDRS Scores

Journal of Integrative Neuroscience
Background: Parkinson’s Disease (PD) is associated with dysregulated/chronic inflammation. The immune system has multiple roles including beneficial effects such as clearing alpha synuclein aggregates.
David Goldeck, Lilly Oettinger, Tamas Fülöp, Claudia Schulte, Klaus Hamprecht, Daniela Berg, Walter Maetzler, Graham Pawelec   +7 more
doaj   +1 more source

Editorial: HDAC inhibition begets more MDSCs [PDF]

Journal of Leukocyte Biology, 2012
Discussion on HDAC inhibition-mediated immune-regulation and generating MDSCs with greater efficiency, both in vitro and in vivo.
openaire   +3 more sources

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Myeloid-Derived Suppressor Cells: Implications in Cancer Immunology and Immunotherapy

Frontiers in Bioscience-Landmark
Myeloid-derived suppressor cells (MDSCs) are believed to be key promoters of tumor development and are recognized as a hallmark of cancer cells’ ability to evade the immune system evasion.
Juan F. Santibanez
doaj   +1 more source

Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells

Frontiers in Cellular and Infection Microbiology, 2018
Staphylococcus aureus is one of the major human bacterial pathogens causing a broad spectrum of serious infections. Myeloid-derived suppressor cells (MDSC) represent an innate immune cell subset capable of regulating host-pathogen interactions, yet their
Hartmut Stoll, Michael Ost, Anurag Singh, Roman Mehling, Davide Neri, Iris Schäfer, Ana Velic, Boris Macek, Dorothee Kretschmer, Christopher Weidenmaier, Andreas Hector, Rupert Handgretinger, Friedrich Götz, Andreas Peschel, Andreas Peschel, Dominik Hartl, Dominik Hartl, Nikolaus Rieber, Nikolaus Rieber, Nikolaus Rieber   +19 more
doaj   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source