Results 71 to 80 of about 43,753 (301)

The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells

Frontiers in Immunology, 2023
Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer.
Claudia Giannotta, Federica Autino, Massimo Massaia, Massimo Massaia   +3 more
doaj   +1 more source

Characterization of Murine Breast Cancer Cell Lines for Anti-Cancer Vaccine [PDF]

, 2017
Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer death among women in the United States (1). While treatments involving radiation and chemotherapy currently exist, disease must be detected early in order
Frazier, Haven N
core   +2 more sources

Dynamic feature selection for clustering high dimensional data streams [PDF]

, 2019
open access articleChange in a data stream can occur at the concept level and at the feature level. Change at the feature level can occur if new, additional features appear in the stream or if the importance and relevance of a feature changes as the ...
Fahy, Conor, Yang, Shengxiang
core   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Frequencies of Circulating Immune Cells in Patients with Parkinson’s Disease: Correlation with MDS-UPDRS Scores

Journal of Integrative Neuroscience
Background: Parkinson’s Disease (PD) is associated with dysregulated/chronic inflammation. The immune system has multiple roles including beneficial effects such as clearing alpha synuclein aggregates.
David Goldeck, Lilly Oettinger, Tamas Fülöp, Claudia Schulte, Klaus Hamprecht, Daniela Berg, Walter Maetzler, Graham Pawelec   +7 more
doaj   +1 more source

Frequent adaptive immune responses against arginase-1

OncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen   +9 more
doaj   +1 more source

Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals

Frontiers in Immunology, 2022
Coronavirus disease 2019 (COVID-19) caused by SARS Coronavirus 2 (CoV2) is associated with massive immune activation and hyperinflammatory response. Acute and severe CoV2 infection is characterized by the expansion of myeloid derived suppressor cells ...
Nadejda Beliakova-Bethell, Nadejda Beliakova-Bethell, Kathirvel Maruthai, Ruijie Xu, Ruijie Xu, Liliana C. M. Salvador, Liliana C. M. Salvador, Liliana C. M. Salvador, Ankita Garg   +8 more
doaj   +1 more source

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function [PDF]

, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
Angus, Badolato, Bernard, Betz, Bozic, Buras, Byl, Cheng, Cheng, Christenson, Christian Trautwein, Delano, Ernst, Fisher, Foreman, Frank Tacke, Gabay, Gabrilovich, Haile, Hoechst, Hotchkiss, Hotchkiss, J. Magarian Blander, Kim, Klein, Kopf, Leif E. Sander, Luchtefeld, Matuschak, Medzhitov, Michael Müller, Movahedi, Murakami, Nagaraj, Naiara Beraza, Nefedova, Parrish, Rebouissou, Reinhold P. Linke, Riedemann, Ritchie, Rittirsch, Rittirsch, Sara Dutton Sackett, Shah, Sinha, Streetz, Tebbutt, Uta Dierssen, Wuestefeld, Yang, Young, Zhu, Zouki   +53 more
core   +4 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Myeloid-Derived Suppressor Cells: Implications in Cancer Immunology and Immunotherapy

Frontiers in Bioscience-Landmark
Myeloid-derived suppressor cells (MDSCs) are believed to be key promoters of tumor development and are recognized as a hallmark of cancer cells’ ability to evade the immune system evasion.
Juan F. Santibanez
doaj   +1 more source