Results 71 to 80 of about 36,927 (297)
Analysis of the functional characteristics of MDSC.
, 2013 Panel A: MDSC were isolated from IL-2 and IL-2+resveratrol treatment (labeled as IL-MDSC and R-MDSC respectively). LAK cells from IL-2 treated mice were isolated and incubated with MDSC for 2 h, and then used as effectors in the cytotoxicity assay ...
Hongbing Guan (248324) +4 more
core +1 more source
Targeting MDSC-mediated immunosuppression in melanoma [PDF]
, 2023 Immunotherapeutic strategies for malignant melanoma have made significant progress but are still challenged by the development of resistance in a subset of patients.
Özbay Kurt, Feyza Gül
core +1 more source
Frontiers in Immunology, 2022 Coronavirus disease 2019 (COVID-19) caused by SARS Coronavirus 2 (CoV2) is associated with massive immune activation and hyperinflammatory response. Acute and severe CoV2 infection is characterized by the expansion of myeloid derived suppressor cells ...
Nadejda Beliakova-Bethell +8 more
doaj +1 more source
Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy
Advanced Materials, EarlyView.MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo +9 more
wiley +1 more source
Functional activity of bone marrow-derived PMN-MDSC and MO-MDSC after CSC.
, 2016 CD11b+Ly6G+Ly6Cint cells (PMN-MDSC) and CD11b+Ly6G-Ly6C+ cells (MO-MDSC) were isolated from bone marrow (BM) or spleen of individual mice after 19d of CSC (black bars, n = 4) or SHC (white bars, n = 4) and stimulated with LPS + IFNγ followed by IL-10 (A)
Dominic Schmidt (130464) +4 more
core +1 more source
Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage. [PDF]
PLoS ONE, 2014 Subcutaneous tumors induce the accumulation of myeloid derived suppressor cells (MDSC) not only in blood and spleens, but also in livers of these animals.
Tobias Eggert +5 more
doaj +1 more source
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
A Unique Pattern of PMN-MDSC Migration in Cancer [PDF]
, 2017 Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of pathologically activated immature myeloid cells that expand and accumulate in cancer, and are categorized as M-MDSC or PMN-MDSC.
Patel, Sima N, Patel, Sima
core
OncoImmunology, 2018 Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor immune evasion. MDSC programming or polarization has been proposed as a strategy for leveraging the developmental plasticity of myeloid cells to reverse MDSC immune ...
Padmini Jayaraman +15 more
doaj +1 more source
Frontiers in Immunology, 2018 The treatment of autoimmune diseases still poses a major challenge, frequently relying on non-specific immunosuppressive drugs. Current efforts aim at reestablishing self tolerance using immune cells with suppressive activity like the regulatory T cells (
Margot Zöller +6 more
doaj +1 more source