Results 51 to 60 of about 36,927 (297)
PMN-MDSC decreased after thawing.
, 2018 A. Gating strategy used to identify MDSC in ex vivo and thawed PBMC: after doublets exclusion (FSC-A/FSC-H), in the morphological gate (FSC/SSC) we excluded debris, then we gated Lin-/HLA DRlow/- cells.
Eleonora Cimini (322110) +8 more
core +1 more source
OncoImmunology, 2018 Immunotherapies have shown promising results in certain cancer patients. For hepatocellular carcinoma (HCC), the multiplicity of an immunotolerant microenvironment within both the tumor, and the liver per se may limit the efficacy of cancer ...
Chia-Jen Wu +9 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
CML-MSC-educated G-MDSC are immunosuppressive.
, 2016 A. HD- and CML-MSC generate similar amount of G-MDSC. The figure shows a representative data from one experiment. Flow cytometry analysis was performed with gates set on CD11b+CD33+CD15+CD14-HLADR- cell population. B.
Vincenzo Bramanti (2501365) +11 more
core +1 more source
OncoImmunology, 2019 Systemic inflammatory responses including thrombocytosis, leukocytosis, or neutrophilia have gained attention as prognostic indicators in patients with various solid malignancies.current study, we aimed to investigate the clinical implications and ...
Eriko Yokoi +13 more
doaj +1 more source
Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism. [PDF]
PLoS ONE, 2011 Myeloid-derived suppressor cells (MDSC) are induced under diverse pathologic conditions, including neoplasia, and suppress innate and adaptive immunity.
Jeremy D Waight +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Tuberculosis can occur during any stage of Human Immunodeficiency virus 1 (HIV) -infection including times when CD4+ T cell numbers have reconstituted and viral replication suppressed.
Priyanka Namdev +3 more
doaj +1 more source
The Engagement Between MDSCs and Metastases: Partners in Crime [PDF]
Frontiers in Oncology, 2020 Tumor metastases represent the major cause of cancer-related mortality, confirming the urgent need to identify key molecular pathways and cell-associated networks during the early phases of the metastatic process to develop new strategies to either prevent or control distal cancer spread. Several data revealed the ability of cancer cells to establish a
Trovato, Rosalinda +5 more
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Expression of immunomodulatoryfactors by MSCedG-MDSC.
, 2016 Compared to HD-, CML-MSCedG-MDSC significantly upregulated ARG1, IL6, IL1β,COX2and TNFα. Calculated value of 2^-ΔΔCt in HD-MSCedG-MDSC was 1.
Vincenzo Bramanti (2501365) +11 more
core +1 more source