Results 41 to 50 of about 36,927 (297)
Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis. [PDF]
PLoS ONE, 2015 CD11b+Gr1+ myeloid derived suppressor cells (MDSC) are known to be very potent suppressors of T cell immunity and can be further stratified into granulocytic MDSC and monocytic MDSC in mice based on expression of Ly6G or Ly6C, respectively.
Bastian Höchst +10 more
doaj +1 more source
Interaction between MdsC or MdsC variants and MdsA in vivo.
, 2014 (A) Protein expression of hexahistidine-tagged MdsC and MdsC variants (MdsC-G220A, MdsC-G433A, and MdsC-L441R), MdsA-Flag and MdsB-Myc was detected by western blotting.
Soonhye Hwang (588045) +4 more
core +1 more source
OncoImmunology, 2017 Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumulation
Chiara Secondini +8 more
doaj +1 more source
New roles of Rb1 in expansion of MDSCs in cancer [PDF]
Cell Cycle, 2013 Although many different mechanisms were implicated in tumor-associated immune deficiency, myeloid-derived suppressor cells (MDSC) are now considered as one of the most prominent factors limiting the ability of immune system to control tumor progression.
Youn, Je-In, Gabrilovich, Dmitry I.
openaire +2 more sources
, 2018 Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid cells that have potent immune-suppressive activity. Studies in both mice and humans have demonstrated that MDSC accumulate in most individuals with cancer, where they ...
Fenselau, Catherine +1 more
core +1 more source
Induction Of Arginase-1 In MDSC Requires Exposure to CD3/CD28 Activated T Cells [PDF]
, 2018 Tumor-induced myeloid derived suppressive cells (MDSC) have been reported to inhibit T cell responses. In our study MDSC isolated from tumor bearing mice showed potent inhibition of T-cell proliferation.
Abdelbaky Abdelaal, Ahmed
core +1 more source
OncoImmunology, 2018 In preclinical models, IL-1β inhibition could enhance the efficacy of fluorouracil (5-FU). In this phase 2 study, we assessed the activity and safety of 5-FU plus bevacizumab and anakinra (an IL-1β and α inhibitor) in patients with metastatic colorectal (
Nicolas Isambert +12 more
doaj +1 more source
Impaired immunosuppressive role of myeloid-derived suppressor cells in acquired aplastic anemia
Haematologica, 2022 Myeloid-derived suppressor cells (MDSC) are a group of heterogeneous immature myeloid cells and display immunosuppressive function. In this study, MDSC populations were evaluated in acquired aplastic anemia (AA) (n=65) in which aberrant immune ...
Peiyuan Dong +14 more
doaj +1 more source
MDSCs in pregnancy and pregnancy-related complications: an update
Biology of Reproduction, 2022 AbstractMaternal–fetal immune tolerance is a process that involves complex interactions of the immune system, and myeloid-derived suppressor cells have emerged as one of the novel immunomodulator in the maintenance of maternal-fetal immune tolerance. Myeloid-derived suppressor cells are myeloid progenitor cells with immunosuppressive activities on both
Neelam Kumari, Shah +9 more
openaire +2 more sources
Connections between Metabolism and Epigenetic Modification in MDSCs [PDF]
International Journal of Molecular Sciences, 2020 Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells in the tumor microenvironment (TME). During the differentiation and development of MDSCs from myeloid progenitor cells, their functions are also affected by a series of regulatory factors in the TME, such as metabolic reprogramming, epigenetic modification, and cell signaling ...
Haiyan Dai +3 more
openaire +2 more sources