Results 21 to 30 of about 43,753 (301)

MIF: metastasis/MDSC-inducing factor? [PDF]

OncoImmunology, 2013
Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor.
Simpson, Kendra D., Cross, Janet V.
openaire   +2 more sources

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]

, 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven, Bronte, Vincenzo, Chen, Shu Hsia, Colombo, Mario P, Frey, Alan B, Gabrilovich, Dmitry I., Greten, Tim F, Mandruzzato, Susanna, Murray, Peter J, Ochoa, Augusto, Ostrand Rosenberg, Suzanne, Rodriguez, Paulo C, Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H   +14 more
core   +2 more sources

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities [PDF]

, 2019
Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the ...
Botti L., Cappetti B., Chiodoni C., Colombo M. P., Consonni F. M., Gulino A., Nicola M. D., Portararo P., Randon G., Sangaletti S., Sica A., Talarico G., Tripodo C.   +12 more
core   +3 more sources

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

OncoImmunology, 2017
Myeloid-derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. Recent reports show that MDSC increase fatty acid uptake and fatty acid oxidation (FAO) to support their immunosuppressive functions.
Amir A. Al-Khami, Liqin Zheng, Luis Del Valle, Fokhrul Hossain, Dorota Wyczechowska, Jovanny Zabaleta, Maria D. Sanchez, Matthew J. Dean, Paulo C. Rodriguez, Augusto C. Ochoa   +9 more
doaj   +1 more source

Switching off MDSCs by targeting REL [PDF]

Nature Reviews Cancer, 2020
Ting Li, Xinyuan Li et al. determined that REL, a member of the nuclear factor-κB (NF-κB) family of transcription factors, has a key role in generating myeloid-derived suppressor cells (MDSCs) and that targeting REL might be used for cancer immunotherapy.
openaire   +2 more sources

DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR– myeloid cells, compared with HLA-DR+ antigen-presenting cells

Epigenetics, 2020
Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses during physiological and pathological conditions.
Reem Saleh, Salman M. Toor, Rowaida Z. Taha, Dana Al-Ali, Varun Sasidharan Nair, Eyad Elkord   +5 more
doaj   +1 more source

Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells

OncoImmunology, 2019
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy.
Marion Dajon, Kristina Iribarren, Florent Petitprez, Solenne Marmier, Audrey Lupo, Mélanie Gillard, Hanane Ouakrim, Navas Victor, Di Bartolo Vincenzo, Pierre Emmanuel Joubert, Oliver Kepp, Guido Kroemer, Marco Alifano, Diane Damotte, Isabelle Cremer   +14 more
doaj   +1 more source

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Adrian J. Thrasher, Arturo Sala, Chow, Croce, Dale, Daniel A. Morgenstern, Giorgia Santilli, Ikeda, Izabela Piotrowska, John Anderson, Katie Pearson, Marco D'Alicarnasso, Nourredine Himoudi, Olesya Chayka, Sandra Cantilena   +14 more
core   +2 more sources

Immunotherapy of targeting MDSCs in tumor microenvironment

Frontiers in Immunology, 2022
Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells which are abnormally accumulated during the differentiation of myeloid cells. Immunosuppression is the main functional feature of MDSCs, which inhibit T cell activity in the tumor microenvironment (TME) and promote tumoral immune escape.
Hongshu Sui, Shengyi Dongye, Xiaocui Liu, Xinghua Xu, Li Wang, Christopher Q. Jin, Minhua Yao, Zhaoqing Gong, Daniel Jiang, Kexin Zhang, Yaling Liu, Yaling Liu, Hui Liu, Guomin Jiang, Yanping Su   +14 more
openaire   +3 more sources

Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [PDF]

, 2019
Despite the fact that solid dispersions are gaining momentum, the number of polymers that have been used as a carrier during the past 50 years is rather limited.
Boel, Eline, De la Rosa, Victor, Hoogenboom, Richard, Smeets, Annelies, Van den Mooter, Guy, Vergaelen, Maarten   +5 more
core   +1 more source