Results 21 to 30 of about 36,927 (297)

Signaling pathways involved in MDSC regulation [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014
The immune system has evolved mechanisms to protect the host from the deleterious effects of inflammation. The generation of immune suppressive cells like myeloid derived suppressor cells (MDSCs) that can counteract T cell responses represents one such strategy.
Prashant, Trikha, William E, Carson
openaire   +2 more sources

Tumor-derived prostaglandin E2 promotes p50 NF-κB-dependent differentiation of monocytic MDSC [PDF]

, 2020
Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) cells that share the ability to suppress adaptive immunity and hinder the effectiveness of anti-cancer treatments.
Sica, Antonio, Mariangela Storto, Claudio Tripodo, Tiziana Pressiani, Doni, Andrea, Sara Morlacchi, Larghi, Paola, Tartari, Silvia, Giulia Soldà, Bleve, Augusto, Storto, Mariangela, Chiara Porta, Silvia Tartari, Emilio Hirsch, Augusto Bleve, Sabina Sangaletti, Ostuni, Renato, Balzac, Fiorella, Colombo, Mario P, Consonni, Francesca Maria, Stefano Duga, Sangaletti, Sabina, Morlacchi, Sara, Fiorella Balzac, Lorenza Rimassa, Laura Strauss, Antonio Sica, Maria G. Totaro, Stefania Banfi, Bronte, Vincenzo, Totaro, Maria Grazia, Gioacchino Natoli, Emilia Turco, Andrea Doni, Tripodo, Claudio, Turco, Emilia, Monica Rimoldi, Renato Ostuni, Mario P. Colombo, Pressiani, Tiziana, Hirsch, Emilio, Rimoldi, Monica, Soldà, Giulia, Francesca M. Consonni, Alessandro Ippolito, Ippolito, Alessandro, Piccolo, Viviana, Rimassa, Lorenza, Porta, Chiara, Paola Larghi, Vincenzo Bronte, Banfi, Stefania, Natoli, Gioacchino, Duga, Stefano, Strauss, Laura, Viviana Piccolo   +55 more
core   +1 more source

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

OncoImmunology, 2017
Myeloid-derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. Recent reports show that MDSC increase fatty acid uptake and fatty acid oxidation (FAO) to support their immunosuppressive functions.
Amir A. Al-Khami, Liqin Zheng, Luis Del Valle, Fokhrul Hossain, Dorota Wyczechowska, Jovanny Zabaleta, Maria D. Sanchez, Matthew J. Dean, Paulo C. Rodriguez, Augusto C. Ochoa   +9 more
doaj   +1 more source

MDSCs in infectious diseases: regulation, roles, and readjustment [PDF]

Cancer Immunology, Immunotherapy, 2018
Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence
Dorhoi, Anca, Glaría, Estibaliz, Garcia-Tellez, Thalia, Nieuwenhuizen, Natalie E, Zelinskyy, Gennadiy, Favier, Benoit, Singh, Anurag, Ehrchen, Jan, Gujer, Cornelia, Münz, Christian, Saraiva, Margarida, Sohrabi, Yahya, Sousa, Ana E, Delputte, Peter, Müller-Trutwin, Michaela, Valledor, Annabel F   +15 more
openaire   +8 more sources

MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer [PDF]

Journal of Clinical Medicine, 2021
Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both humans and mice and their presence is linked to poor clinical outcomes for cancer patients. Studying MDSC immunosuppression is restricted by MDSCs’ rarity, short lifespan, heterogeneity, poor viability after freezing and the lack of MDSC-specific markers.
Vanhaver, Christophe, van der Bruggen, Pierre, Bruger, Annika M.   +2 more
openaire   +2 more sources

Switching off MDSCs by targeting REL [PDF]

Nature Reviews Cancer, 2020
Ting Li, Xinyuan Li et al. determined that REL, a member of the nuclear factor-κB (NF-κB) family of transcription factors, has a key role in generating myeloid-derived suppressor cells (MDSCs) and that targeting REL might be used for cancer immunotherapy.
openaire   +2 more sources

PMA induces the differentiation of monocytes into immunosuppressive MDSCs [PDF]

Clinical and Experimental Immunology, 2021
Abstract The induction of immune tolerance without the use of immunosuppressive drugs is a crucial problem in organ transplantation. The use of myeloid-derived suppressor cells (MDSCs) as a cell-based adjuvant immunosuppressive therapy is a bright clinical prospect in organ transplantation.
Haozhou Wang, JiaWei Ji, Yuan Zhuang, Xiaoguang Zhou, Yong Zhao, Xiaodong Zhang   +5 more
openaire   +2 more sources

Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells

OncoImmunology, 2019
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy.
Marion Dajon, Kristina Iribarren, Florent Petitprez, Solenne Marmier, Audrey Lupo, Mélanie Gillard, Hanane Ouakrim, Navas Victor, Di Bartolo Vincenzo, Pierre Emmanuel Joubert, Oliver Kepp, Guido Kroemer, Marco Alifano, Diane Damotte, Isabelle Cremer   +14 more
doaj   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma [PDF]

Advanced science
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Zhang D, Cai Y, Zhang J, Zhang J, Jing R, Cai M.   +5 more
europepmc   +2 more sources

Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma

OncoImmunology, 2018
Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease.
Laura Pinton, Samantha Solito, Elena Masetto, Marina Vettore, Stefania Canè, A. Della Puppa, Susanna Mandruzzato   +6 more
doaj   +1 more source