Results 31 to 40 of about 43,753 (301)

Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients

OncoImmunology, 2020
The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying immune mechanisms impacting survival of HCC patients have not been investigated.
Suresh Gopi Kalathil, Katy Wang, Alan Hutson, Renuka Iyer, Yasmin Thanavala   +4 more
doaj   +1 more source

Myeloid - derived suppressor cells in Type 1 diabetes are an expanded population exhibiting diverse T-cell suppressor mechanisms.

PLoS ONE, 2020
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous group of immature myeloid cells with immunoregulatory function in cancer and autoimmune diseases. In humans, two subsets of MDSC were determined based on the characteristic surface markers,
Anna Grohová, Klára Dáňová, Irena Adkins, Zdeněk Šumník, Lenka Petruželková, Barbora Obermannová, Stanislava Koloušková, Radek Špíšek, Lenka Palová-Jelínková   +8 more
doaj   +2 more sources

Editorial: HDAC inhibition begets more MDSCs [PDF]

Journal of Leukocyte Biology, 2012
Discussion on HDAC inhibition-mediated immune-regulation and generating MDSCs with greater efficiency, both in vitro and in vivo.
openaire   +3 more sources

Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma

OncoImmunology, 2018
Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease.
Laura Pinton, Samantha Solito, Elena Masetto, Marina Vettore, Stefania Canè, A. Della Puppa, Susanna Mandruzzato   +6 more
doaj   +1 more source

Move over Tregs, MDSCs are here [PDF]

Blood, 2016
In this issue of Blood, Hou et al show the involvement of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of immune thrombocytopenia (ITP) and identify a novel mechanism by which high-dose dexamethasone (HD-DXM) promotes MDSC expansion and function and correlates with increased platelet counts.
openaire   +2 more sources

A novel MDSC-induced PD-1−PD-L1+ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties

OncoImmunology, 2018
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that suppress T-cell activity in a tumor microenvironment. However, the suppressive function of MDSCs on B cells and its underlying mechanism remain unclear.
Meng Shen, Jian Wang, Wenwen Yu, Chen Zhang, Min Liu, Kaiyuan Wang, Lili Yang, Feng Wei, Shizhen Emily Wang, Qian Sun, Xiubao Ren   +10 more
doaj   +1 more source

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Frontiers in Oncology, 2022
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells derived from bone marrow that play critical immunosuppressive functions in the tumor microenvironment (TME), promoting cancer progression. According to base length, Non-coding RNAs (ncRNAs) are mainly divided into: microRNAs (miRNAs), lncRNAs, snRNAs and CircRNAs. Both
Xiaocui Liu, Shang Zhao, Hongshu Sui, Hui Liu, Minhua Yao, Yanping Su, Peng Qu, Peng Qu   +7 more
openaire   +3 more sources

Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma [PDF]

, 2016
Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics.
Basso, Giuseppe, Buffardi, Salvatore, Burnelli, Roberta, Carraro, Elisa, Elia, Caterina, Farruggia, Piero, Mascarin, Maurizio, Mussolin, Lara, Pillon, Marta, Primerano, Simona, Sala, Alessandra, Vinti, Luciana   +11 more
core   +2 more sources

Disorder Induced Stripes in d-Wave Superconductors [PDF]

, 2012
Stripe phases are observed experimentally in several copper-based high-Tc superconductors near 1/8 hole doping. However, the specific characteristics may vary depending on the degree of dopant disorder and the presence or absence of a low- temperature ...
Arno P Kampf, Berg E, Florian Loder, Fresard R, Jiang H-M, Loder F, Markus Schmid, Razzoli E, Scalapino D J, Schmid M, Schmid M, Thilo Kopp, Yang K-Y, Yu M Kagan, Zimmermann M V   +14 more
core   +2 more sources

Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patients

OncoImmunology, 2019
Nivolumab, a monoclonal antibody targeting PD-1, is currently approved for metastatic non-small cell lung cancer (mNSCLC) treatment after failure of first-line chemotherapy.
Emeric Limagne, Corentin Richard, Marion Thibaudin, Jean-David Fumet, Caroline Truntzer, Aurélie Lagrange, Laure Favier, Bruno Coudert, François Ghiringhelli   +8 more
doaj   +1 more source