Results 31 to 40 of about 36,927 (297)

Myeloid - derived suppressor cells in Type 1 diabetes are an expanded population exhibiting diverse T-cell suppressor mechanisms.

PLoS ONE, 2020
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous group of immature myeloid cells with immunoregulatory function in cancer and autoimmune diseases. In humans, two subsets of MDSC were determined based on the characteristic surface markers,
Anna Grohová, Klára Dáňová, Irena Adkins, Zdeněk Šumník, Lenka Petruželková, Barbora Obermannová, Stanislava Koloušková, Radek Špíšek, Lenka Palová-Jelínková   +8 more
doaj   +2 more sources

G-MDSC-derived exosomes mediate the differentiation of M-MDSC into M2 macrophages promoting colitis-to-cancer transition

, 2023
Backgrounds In inflammatory bowel disease microenvironment, transdifferentiation of myeloid-derived suppressor cells (MDSCs) and M2 macrophage accumulation are crucial for the transition of colitis-to-cancer.
Yungang Wang, Dezhi Bian, Yanxia Ding, Shengjun Wang, Hongli Liu, Zhe Zhang, Keke Shao   +6 more
core   +1 more source

MDSC

Proceedings of the 14th IEEE/ACM International Conference on Utility and Cloud Computing Companion, 2021
The growth of the Internet of Things is resulting in an explosion of data volumes at the Edge of the Internet. To reduce costs incurred due to data movement and centralized cloud-based processing, it is becoming increasingly important to process and analyze such data closer to the data sources.
Balouek-Thomert, Daniel, Silva, Pedro, Fauvel, Kevin, Costan, Alexandru, Antoniu, Gabriel, Parashar, Manish   +5 more
openaire   +2 more sources

DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR– myeloid cells, compared with HLA-DR+ antigen-presenting cells

Epigenetics, 2020
Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses during physiological and pathological conditions.
Reem Saleh, Salman M. Toor, Rowaida Z. Taha, Dana Al-Ali, Varun Sasidharan Nair, Eyad Elkord   +5 more
doaj   +1 more source

Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patients

OncoImmunology, 2019
Nivolumab, a monoclonal antibody targeting PD-1, is currently approved for metastatic non-small cell lung cancer (mNSCLC) treatment after failure of first-line chemotherapy.
Emeric Limagne, Corentin Richard, Marion Thibaudin, Jean-David Fumet, Caroline Truntzer, Aurélie Lagrange, Laure Favier, Bruno Coudert, François Ghiringhelli   +8 more
doaj   +1 more source

Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Zenghua Deng,1,2,* Kanghua Huang,3,* Dongfang Liu,1 Nan Luo,1,2 Tingting Liu,1 Long Han,1 Dexiao Du,1 Dongbo Lian,1,2 Zhaohui Zhong,4 Jirun Peng1,2 1Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038 ...
Deng Z, Huang K, Liu D, Luo N, Liu T, Han L, Du D, Lian D, Zhong Z, Peng J   +9 more
doaj  

Influence of the molecular subtype of epithelial ovarian cancer on MDSC induction

, 2023
noneMyeloid derived suppressor cells (MDSC) represent a heterogeneous group of cells which expansion was first associate to the presence of cancer. MDSC are functionally defined as suppressive of the T cell activation, which as a consequence positively ...
DIAMANTE, GABRIELE
core  

Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients

OncoImmunology, 2020
The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying immune mechanisms impacting survival of HCC patients have not been investigated.
Suresh Gopi Kalathil, Katy Wang, Alan Hutson, Renuka Iyer, Yasmin Thanavala   +4 more
doaj   +1 more source

Move over Tregs, MDSCs are here [PDF]

Blood, 2016
In this issue of Blood, Hou et al show the involvement of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of immune thrombocytopenia (ITP) and identify a novel mechanism by which high-dose dexamethasone (HD-DXM) promotes MDSC expansion and function and correlates with increased platelet counts.
openaire   +2 more sources

Upregulated TRAIL and Reduced DcR2 Mediate Apoptosis of Decidual PMN-MDSC in Unexplained Recurrent Pregnancy Loss

Frontiers in Immunology, 2020
Myeloid-derived suppressor cells (MDSC), especially polymorphonuclear MDSC (PMN-MDSC), accumulate in maternal-fetal interface during pregnancy and are involved in the maintenance of immune tolerance.
Congcong Li, Congcong Li, Xiaoxin Zhang, Xiaomin Kang, Chao Chen, Chao Chen, Feng Guo, Feng Guo, Qiaohong Wang, Qiaohong Wang, Aimin Zhao, Aimin Zhao   +11 more
doaj   +1 more source