Results 11 to 20 of about 36,927 (297)
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation [PDF]
Journal for ImmunoTherapy of Cancer, 2020 Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant and ...
Ang Lin +43 more
doaj +2 more sources
The Role of CCR5 in the Recruitment of MDSC to the Tumor Microenvironment [PDF]
, 2016 The aim of the study was to analyze the recruitment and accumulation of MDSC in the tumor microenvironment via C-C chemokine receptor type 5 (CCR5)/CRR5 ligand interaction, as well as immunosuppressive activity of CCR5-expressing tumor-infiltrating MDSC.
Blattner, Carolin
openaire +2 more sources
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid-derived suppressor cells. [PDF]
FEBS Open BioBCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Chen Y, Li H.
europepmc +2 more sources
AIDS, 2012 Myeloid-derived suppressor cells (MDSCs) were initially described more than 2 decades ago as bone marrow suppressor cells in mice with metastatic lung tumors [1]. In the past several years, there has been increasing interest in their role in cancer immune regulation [2,3].
Bernard J C, Macatangay +2 more
openaire +2 more sources
PMN-MDSC in newborns: Regulation of the regulators
Journal of Leukocyte Biology, 2022 AbstractPMN-MDSC are pathologically activated neutrophils that acquire T cell (and NK cell) suppressive activity and thus function as negative regulators of effector lymphocytes in many disease conditions.[1] For many years, these PMN-MDSC have mainly been seen as contributors to disease progression and severity, best exemplified in the context of ...
Jablonska, Jadwiga, Brandau, Sven
openaire +3 more sources
Fatal attraction: TICs and MDSCs [PDF]
Cell Cycle, 2016 We recently observed that the propensity to induce MDSC accumulation varies greatly between different mammary tumors.
Thomas, Welte +2 more
openaire +2 more sources
Immunotherapy of targeting MDSCs in tumor microenvironment
Frontiers in Immunology, 2022 Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells which are abnormally accumulated during the differentiation of myeloid cells. Immunosuppression is the main functional feature of MDSCs, which inhibit T cell activity in the tumor microenvironment (TME) and promote tumoral immune escape.
Hongshu Sui +14 more
openaire +3 more sources
The Effect of Immunosuppressive Drugs on MDSCs in Transplantation [PDF]
Journal of Immunology Research, 2018 Myeloid-derived suppressor cells (MDSCs) are a group of innate immune cells that regulates both innate and adaptive immune responses. In recent years, MDSCs were shown to play an important negative regulatory role in transplant immunology even upstream of regulatory T cells.
Fan Yang +5 more
openaire +3 more sources
Editorial: Dexamethasone and MDSC in transplantation: yes to NO [PDF]
Journal of Leukocyte Biology, 2014 Discussion on the manipulation of myeloid suppressor cells as a novel therapeutic approach in organ transplantation.
J C, Ochando, P, Conde
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Studio dell'effetto immunomodulante di cellule soppressorie di derivazione mieloide (MDSC) in un modello di allotrapianto di isole pancreatiche nel topo. [PDF]
, 2022 In corso di fenomeni neoplastici si verifica una profonda dismielopoiesi associata allo sviluppo di cellule immunosoppressorie di derivazione mielode (Myeloid‐derived suppressor cells, MDSC), che favoriscono l’accettazione del tumore e la sua ...
Fassina, Alessandra
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