Results 191 to 200 of about 36,927 (297)

Pre-existing systemic immune state and dynamic myeloid remodeling shape response to neoadjuvant PD-L1 blockade. [PDF]

J Immunother Cancer
Kasper S, Winkel H, Höing B, Bruderek K, Pogorzelski M, Deuss E, Grünewald I, Doreth C, Wang X, Theurer S, Arakawa-Hoyt J, Maitra S, Guberina M, Virchow I, Schuler M, Spitzer MH, Lang S, Kürten CH, Brandau S.   +18 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Glioblastoma stem cell-immune microenvironment crosstalk: molecular mechanisms and therapeutic opportunities. [PDF]

Front Immunol
Xu C, Chai L, Yuan W.
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Myeloid-Derived Suppressor Cells (MDSCs) in Cardiovascular Risk of Obesity-Associated Diabetes. [PDF]

Int J Mol Sci
Flores-Campos R, Hontecillas-Prieto L, García-Domínguez DJ, Fernández-Suárez A, Egusquiza-Lasuen I, Pérez A, Ribalta J, Pedro-Botet J, Sánchez-Margalet V, On Behalf Of The Immunology Group Of The Spanish Society Of Laboratory Medicine Semedlab, The Cardiovascular Disease Group Of The Spanish Diabetes Society Sed.   +10 more
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Inhibiting CXCR2 Remodels the Tumor Microenvironment and Blunts Tumor Progression and Dissemination of High-Grade Serous Carcinoma. [PDF]

Cancer Res Commun
Mikeska RG, Feldman LER, Woodruff ER, Iwanaga R, Linder KE, Yamamoto TM, Sompel K, Jordan KR, Post MD, Zoller M, Bitler BG, Marjon NA.   +11 more
europepmc   +1 more source

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

Cancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima, Tomomi Uchiyama, Kazuki Funayama, Yuto Goto, Akari Mukaimine, Naoya Ieda, Mikako Ogawa   +6 more
wiley   +1 more source

B7-H3 (CD276) regulates myeloid-derived suppressor cell differentiation in pulmonary fibrosis. [PDF]

Front Immunol
Gonzalez De Los Santos F, Rosek A, Ando A, Phan SH, Mahadevan NR, Liu T.   +5 more
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source