Results 201 to 210 of about 43,753 (301)

CD55-expressing myeloid-derived suppressor cells (MDSCs) drive cancer immunoevasion. [PDF]

J Immunother Cancer
Jiang X, Yan N, Wu H, Wang W, Wang X, Chen J, Wu A, An J, Wang C, Lin J, Li Y, Wen Y, Zhuang K, Xie L, Li P, Liu F, Liu Y.   +16 more
europepmc   +1 more source

IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

Journal of Gastroenterology and Hepatology, EarlyView.
Combined IL‐15 and thymosin α1 therapy reverses CD8+ T cell senescence in hepatocellular carcinoma via a “supply and boost” strategy. Tα1 restores thymic naïve T cell output, while IL‐15 enhances peripheral effector function. Mechanistically, this combination suppresses overactivated PI3K/AKT signaling, restoring antitumor immunity and prolonging ...
Fengtian Wu, Zixuan Guo, Jun Guan, Jia Xu, Yao Chen, Zhi Chen   +5 more
wiley   +1 more source

Downregulated Smad3 signaling impairs the maturation of MO-MDSC in colorectal cancer. [PDF]

Cell Death Dis
Li M, Zha X, Gao Z, Zhao Y, Ma J, Tian J, Mao Z, Wang S.   +7 more
europepmc   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

CTSC Confers Radioresistance in Hepatocellular Carcinoma by Regulating Myeloid-Derived Suppressor Cells. [PDF]

J Cell Mol Med
Xu J, Zhang B, Yang S, Song S, Wu J, Dang Y.   +5 more
europepmc   +1 more source

Early‐Onset Oral Squamous Cell Carcinoma: Emerging Biological Insights, Risk Factors and Clinical Implications

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Early‐onset oral squamous cell carcinoma (EO‐OSCC), commonly defined as occurring in individuals under 50 years of age, is increasingly recognized as a potentially distinct clinical subset with differences in exposure patterns and tumor biology compared with conventional oral squamous cell carcinoma (OSCC).
Gennaro Musella, Cristina D'Antonio, Federica Canfora, Michele D. Mignogna, Valentino Vellone, Vito Carlo Alberto Caponio, Amerigo Giudice, Alessandro Villa, Daniela Adamo   +8 more
wiley   +1 more source

6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells. [PDF]

Nat Commun
Daneshmandi S, Yan Q, Gomez EC, Choi JE, Katsuta E, Gharib E, Singh PK, Higashi RM, Lane AN, Fan TW, Wang J, Repasky EA, McCarthy PL, Mohammadpour H.   +13 more
europepmc   +1 more source

Further caracterisation of MDSC subpopulations

Further caracterisation of MDSC ...
openaire   +1 more source

Immunomodulatory effects of photodynamic therapy for skin cancer: Potential strategies to improve treatment efficacy and tolerability

Photochemistry and Photobiology, EarlyView.
Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio, Sanjay Anand, Jeffrey B. Travers, Edward V. Maytin, Craig A. Rohan   +4 more
wiley   +1 more source

The CDK inhibitor Roscovitine enhances the therapeutic efficacy of anti-PD-1 in non-small cell lung cancer. [PDF]

Front Oncol
Diaz-Montero CM, Holvey-Bates EG, Rayman PA, Parker Y, Lindner DJ, Stark GR, De S.   +6 more
europepmc   +1 more source