Results 231 to 240 of about 43,753 (301)

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Cannabidiol suppresses emergency MDSCs generation by disturbing EEF1B2-mediated C/EBP<i>β</i> protein synthesis in colorectal adenomas. [PDF]

J Immunother Cancer
Pan J, Zhao L, Du H, Zhu Y, Sun X, Xu Q, Cheng H, Chen H, Sun Y.   +8 more
europepmc   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, Volume 13, Issue 26, 8 May 2026.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [PDF]

Eur J Immunol
Schwarz J, Hebel J, Dietz-Ziegler S, Rühle J, Lajqi T, Orlikowsky T, Poets CF, Gille C, Köstlin-Gille N.   +8 more
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

The vasoprotective role of Myeloid-derived suppressor cells in pathogenesis of aortic dissection. [PDF]

Sci Rep
Xu Z, Wang H, Lin Z, Chen L, Dai X.
europepmc   +1 more source

A Versatile Polymer‐Based In Situ Nanovaccine to Boost Cancer Immunotherapy

Aggregate, Volume 7, Issue 5, May 2026.
A polymer‐based in situ nanovaccine (PCR‐NPs) orchestrates a powerful antitumor immune cascade via integrated antigen release, capture, and lymph nodes transport, eliciting potent CD8+ T cell responses that drive significant tumor inhibition and prolonged mice survival in murine tumor models.
Qi‐Song Tong, Na Shu, Hua Huang, Wei Xu, Wen‐Chuan Xie, Quan Xia, Jin‐Zhi Du   +6 more
wiley   +1 more source

Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer. [PDF]

World J Oncol
AlRammah T, Wu R, Chida K, Kawashima K, Hakamada K, Ishikawa T, Ebos JML, Takabe K.   +7 more
europepmc   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source

Quantification of microplastics in complex environmental matrices using a tiered approach with modulated differential scanning calorimetry (MDSC). [PDF]

Anal Bioanal Chem
Leng Y, Gaburici L, Cao X, Zou S.
europepmc   +1 more source