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MDSC: Markers, development, states, and unaddressed complexity
Immunity, 2021Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities in immunology. While the context and classification of this group of cells has evolved, MDSCs most commonly describe cells arising during chronic inflammation, especially late-stage cancers, and are defined by their T cell immunosuppressive functions.
Samarth Hegde, Miriam Merad
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Targeting YTHDF2/MDSCs to improve radiotherapy
Cell Chemical Biology, 2023Immunosuppression contributes to tumor-radiotherapy failure, but the mechanism remains elusive. Wang et al.1 reported that ionizing radiation (IR) induces YTHDF2 expression in myeloid-derived suppressor cells (MDSCs) via an IR-YTHDF2-NF-κB circuit, which contributes to MDSC expansion/migration and treatment failure. Genetic depletion or pharmacological
Xiaolan, Deng, Ying, Qing, Jianjun, Chen
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Signaling pathways involved in MDSC regulation [PDF]
Biochimica Et Biophysica Acta: Reviews on Cancer, 2014 The immune system has evolved mechanisms to protect the host from the deleterious effects of inflammation. The generation of immune suppressive cells like myeloid derived suppressor cells (MDSCs) that can counteract T cell responses represents one such strategy.
William E Carson Iii
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MDSCs sneak CSCs out of (immuno)surveillance
Trends in Immunology, 2022Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of ...
Carlos Jiménez-Cortegana +2 more
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Nature Reviews Immunology, 2020
A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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Monocytic MDSCs regulate macrophage-mediated xenogenic cytotoxicity
Transplant Immunology, 2015Xenotransplantation is considered to be one of the most attractive strategies for overcoming the worldwide shortage of organs. However, many obstructions need to be overcome before it will achieve clinical use in patients. One such obstacle is the development of an effective immunosuppressive strategy.
Akira, Maeda +10 more
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Tumor-related stress regulates functional plasticity of MDSCs
Cellular Immunology, 2021Myeloid-derived suppressor cells (MDSCs) impair protective anti-tumor immunity and remain major obstacles that stymie the effectiveness of promising cancer therapies. Diverse tumor-derived stressors galvanize the differentiation, intra-tumoral expansion, and immunomodulatory function of MDSCs.
Jessica K. Mandula, Paulo C. Rodriguez
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Phenotypic Plasticity of MDSC in Cancers
Immunological Investigations, 2012Myeloid-derived suppressor cells (MDSCs) were initially reported as suppressor of the adaptive immune responses against cancer and other diseases. However, emerging evidence suggest that MDSCs may also support anti-tumor immune responses under certain conditions or may inhibit tumor growth.
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Science, 2020
Tumor Immunology Myeloid-derived suppressor cells (MDSCs) are immune cells that mediate immune suppression and are correlated with progressing cancer. How these cells arise and whether they can be therapeutically targeted akin to exhausted T cells are areas of active investigation. A persistent challenge in studying MDSCs has been the identification of
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Tumor Immunology Myeloid-derived suppressor cells (MDSCs) are immune cells that mediate immune suppression and are correlated with progressing cancer. How these cells arise and whether they can be therapeutically targeted akin to exhausted T cells are areas of active investigation. A persistent challenge in studying MDSCs has been the identification of
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