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International Immunopharmacology, 2011 Myeloid derived suppressor cells (MDSC) were first described nearly two decades ago. Until recently, however, descriptions of MDSC populations were found almost exclusively in animal models of cancer or in cancer patients. Over the last few years, an increasing number of reports have been published describing populations of myeloid cells with MDSC-like
James D Gorham
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Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model [PDF]
Cancer Immunology, Immunotherapy, 2020 Pancreatic ductal adenocarcinoma is characterized by a strong immunosuppressive network with a dense infiltration of myeloid cells including myeloid-derived suppressor cells (MDSC).
Max Schnurr +2 more
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High M-MDSC Percentage as a Negative Prognostic Factor in Chronic Lymphocytic Leukaemia
Cancers, 2020 In the current study, we analysed the role and prognostic value of myeloid-derived suppressor cells (MDSC) in chronic lymphocytic leukaemia (CLL). The frequency of circulating monocytic MDSC (M-MDSC; defined as CD14+CD11b+CD15-HLA-DR-/low cells) was ...
Izabela Morawska +2 more
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MDSCs, ageing and inflammageing
Cellular Immunology, 2021The challenge of distinguishing between changes attributable to ageing and those attributable to pathology is even greater for the immune system than for many other organs, and this is especially true for myeloid-derived suppressor cells (MDSCs). Hematopoiesis is different in older adults with a bias towards myelopoiesis, and older adults also manifest
Graham, Pawelec +4 more
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European Journal of Immunology, 2020 In contrast to the mouse, functional assets of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) in the human spleen remain to be better elucidated.
Hamdullah Yanik +2 more
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Targeting YTHDF2/MDSCs to improve radiotherapy
Cell Chemical Biology, 2023Immunosuppression contributes to tumor-radiotherapy failure, but the mechanism remains elusive. Wang et al.1 reported that ionizing radiation (IR) induces YTHDF2 expression in myeloid-derived suppressor cells (MDSCs) via an IR-YTHDF2-NF-κB circuit, which contributes to MDSC expansion/migration and treatment failure. Genetic depletion or pharmacological
Xiaolan, Deng, Ying, Qing, Jianjun, Chen
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PMN-MDSC and arginase are increased in myeloma and may contribute to resistance to therapy
Expert Review of Molecular Diagnostics, 2018 Objectives: Despite improvement in overall response due to the introduction of the first-in-class proteasome inhibitor bortezomib (btz), multiple myeloma (MM) is still an incurable disease due to the immune-suppressive bone marrow (BM) environment. Thus,
Daniele Tibullo +2 more
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MDSCs sneak CSCs out of (immuno)surveillance
Trends in Immunology, 2022Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of ...
Carlos Jiménez-Cortegana +2 more
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