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Science, 2020
Tumor Immunology Myeloid-derived suppressor cells (MDSCs) are immune cells that mediate immune suppression and are correlated with progressing cancer. How these cells arise and whether they can be therapeutically targeted akin to exhausted T cells are areas of active investigation. A persistent challenge in studying MDSCs has been the identification of
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Tumor Immunology Myeloid-derived suppressor cells (MDSCs) are immune cells that mediate immune suppression and are correlated with progressing cancer. How these cells arise and whether they can be therapeutically targeted akin to exhausted T cells are areas of active investigation. A persistent challenge in studying MDSCs has been the identification of
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Phenotypic Plasticity of MDSC in Cancers
Immunological Investigations, 2012Myeloid-derived suppressor cells (MDSCs) were initially reported as suppressor of the adaptive immune responses against cancer and other diseases. However, emerging evidence suggest that MDSCs may also support anti-tumor immune responses under certain conditions or may inhibit tumor growth.
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Nature Reviews Immunology, 2020
A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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Abstract 755: Antagonistic effect of M-MDSC and N-MDSC during astrocytoma progression
Cancer Research, 2016Abstract The traditional dogma holds that tumor size has a positive correlation with tumor progression. However, on murine orthotopical astrocytoma model ALTS1C1, we found that the tumor growth is not a linear function instead a shrinkage and regrowth wave was noticed.
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MDSCs in bone metastasis: Mechanisms and therapeutic potential
Cancer LettersBone metastasis (BM) is a frequent complication associated with advanced cancer that significantly increases patient mortality. Myeloid-derived suppressor cells (MDSCs) play a pivotal role in BM progression by promoting angiogenesis, inhibiting immune responses, and inducing osteoclastogenesis. MDSCs induce immunosuppression through diverse mechanisms,
Zhi Li +4 more
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New insights into the functions of MDSCs in autoimmune pathogenesis
Cellular & Molecular Immunology, 2023Ke Rui +4 more
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Myeloid-derived suppressor cells (MDSC): When good intentions go awry
Cellular Immunology, 2021Maria Dulfary Sanchez-Pino +1 more
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Myeloid-Derived Suppressor Cells (MDSC) in Melanoma Patients Treated with Anti-PD-1 Immunotherapy
Cells, 2023Andrzej Mackiewicz +2 more
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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis
Cell Reports, 2022Hua Han, Liang Wang, Jun-Long Zhao
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