Results 241 to 250 of about 1,372,524 (319)

Tanshinones target drug-resistant tuberculosis: efficacy, selectivity, and potential mechanism of action. [PDF]

RSC Med Chem
Polinário G, Rosa MABC, Campos DL, Moraes LLS, de Campos MMA, Silva IGM, Barros-Cordeiro KB, Báo SN, Pavan FR.   +8 more
europepmc   +1 more source

MECHANISMS OF HORMONE ACTION

British Journal of Anaesthesia, 1981
openaire   +2 more sources

Problematic aspects of law enforcement activities of the penal system in the preventive action mechanism in relation of persons serving sentences without imprisonment

Bronislav Kazak, Iuliia Smirnova, И.С. Бычинская   +2 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Rethinking miRNAs in MSC-sEV therapeutics: implications for manufacture, mechanism of action, and development of robust potency CQAs. [PDF]

Extracell Vesicles Circ Nucl Acids
Tan TT, Lim SK.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effective components of Coptidis Rhizoma and Cinnamomi Cortex in the treatment of renal cell carcinoma and their mechanism of action. [PDF]

Medicine (Baltimore)
Duan D, Wang J, Chen M, Tan L, Song L.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511. [PDF]

Front Pharmacol
Deng X, Hu C, Li L, Yang G, Li C, Zhang W, Cheng G.   +6 more
europepmc   +1 more source

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex. [PDF]

Cancer Discov
Yuan L, Ji W, Dwyer BG, Lu J, Bian J, Colombo GM, Martinez MJ, Fernandez D, Phillips NA, Tang MT, Zhou CW, Quispe Calla NE, Guzman Huancas C, Eckart M, Tran J, Jones HM, Qiu T, Doench JG, Rees MG, Roth JA, Cameron MD, Charville GW, Kuo CJ, Dixon SJ, Zhang T, Hinshaw SM, Gray NS, Corsello SM.   +27 more
europepmc   +1 more source