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Decoding force-transmission linkages for therapeutic targeting and engineering [PDF]
APL BioengineeringMechanosensing and mechanotransduction enable cells to perceive and respond to mechanical forces, underpinning essential physiological processes and disease pathways.
Jingzhun Liu, Yunxin Deng, Jie Yan
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MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap [PDF]
Nature CommunicationsThe tactile sense is essential for living organisms. However, the molecular mechanisms of mechanosensing in plants remain unclear. The Venus flytrap (Dionaea muscipula), a carnivorous plant, possesses mechanosensitive organs called sensory hairs.
Hiraku Suda +6 more
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Taming Variability in T-Cell Mechanosensing [PDF]
CellsA central step in T-cell immunotherapy is the expansion of a starting population into therapeutically potent numbers of these “living drugs”. This process can be enhanced by replacing the mechanically stiff materials used for activation with softer ...
Paula J. Schultheiss +3 more
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iScience, 2023 Summary: The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast maturation via a process called mechanosensing. Although in the aging male heart, ECM is stiffer than in the young mouse, myofibroblast development is ...
Aude Angelini +4 more
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Caveolae couple mechanical stress to integrin recycling and activation
eLife, 2022 Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process in which integrins play an important role. During cellular mechanosensing, plasma membrane (PM)
Fidel-Nicolás Lolo +8 more
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Cells, 2021 The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases.
Lucrezia Bruno +5 more
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HortTechnology, 2021 Mechanical stimulation to produce stable and high-quality crops under greenhouse conditions is a promising alternative to chemical growth retardants. However, plant tissue damage and the lack of full automatization have been major constraints for large ...
Marc-André Sparke +5 more
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Mechanosensitive Regulation of Fibrosis
Cells, 2021 Cells in the human body experience and integrate a wide variety of environmental cues. A growing interest in tissue mechanics in the past four decades has shown that the mechanical properties of tissue drive key biological processes and facilitate ...
Shuying Yang, Sergey V. Plotnikov
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Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction
Cells, 2021 Body implants and implantable medical devices have dramatically improved and prolonged the life of countless patients. However, our body repair mechanisms have evolved to isolate, reject, or destroy any object that is recognized as foreign to the ...
Nina Noskovicova +2 more
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Journey to the Center of the Cell: Cytoplasmic and Nuclear Actin in Immune Cell Functions
Frontiers in Cell and Developmental Biology, 2021 Actin cytoskeletal dynamics drive cellular shape changes, linking numerous cell functions to physiological and pathological cues. Mutations in actin regulators that are differentially expressed or enriched in immune cells cause severe human diseases ...
Julien Record +5 more
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