Results 11 to 20 of about 10,274 (232)
Emerging Topics in Life Sciences, 2018 Structural links from the nucleus to the cytoskeleton and to the extracellular environment play a role in direct mechanosensing by nuclear factors. Here, we highlight recent studies that illustrate nuclear mechanosensation processes ranging from DNA repair and nuclear protein phospho-modulation to chromatin reorganization, lipase activation by dilation,
Yuntao Xia +4 more
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Assaying mechanosensation [PDF]
WormBook, 2014 C. elegans detect and respond to diverse mechanical stimuli using neuronal circuitry that has been defined by decades of work by C. elegans researchers. In this WormMethods chapter, we review and comment on the techniques currently used to assess mechanosensory response. This methods review is intended both as an introduction for those new to the field
Martin, Chalfie +3 more
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Gels, 2021 Cell encapsulating scaffolds are necessary for the study of cellular mechanosensing of cultured cells. However, conventional scaffolds used for loading cells in bulk generally fail at low compressive strain, while hydrogels designed for high toughness ...
Zain Clapacs +7 more
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Mechanosensation in leaf veins [PDF]
Science Advances, 2023 Whether the plant vasculature has the capacity to sense touch is unknown. We developed a quantitative assay to investigate touch-response electrical signals in the leaves and veins of Arabidopsis thaliana . Mechanostimulated electrical signaling in leaves displayed strong diel regulation.
Tsu-Hao Yang +3 more
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Generation of stress fibers through myosin-driven reorganization of the actin cortex
eLife, 2021 Contractile actomyosin bundles, stress fibers, govern key cellular processes including migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental morphogenesis. The most prominent actomyosin bundles, ventral stress fibers,
Jaakko I Lehtimäki +3 more
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Advanced Science, 2023 The development of bioelectronic neural implant technologies has advanced significantly over the past 5 years, particularly in brain–machine interfaces and electronic medicine. However, neuroelectrode‐based therapies require invasive neurosurgery and can
Alexandre Trotier +8 more
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Working a second job: Cell adhesion proteins that moonlight in the nucleus
Frontiers in Cell and Developmental Biology, 2023 Cells are adept at sensing changes in their environment, transmitting signals internally to coordinate responses to external stimuli, and thereby influencing adaptive changes in cell states and behavior.
Amanda Haage, Archana Dhasarathy
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Mechanosensing and fibrosis [PDF]
Journal of Clinical Investigation, 2018 Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture and function. The failure to resolve injury and restore homeostasis gives rise to progressive fibrosis that is accompanied by persistent alterations in the mechanical environment as a consequence of pathological matrix deposition and stiffening.
Daniel J. Tschumperlin +3 more
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Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone
Cells, 2020 Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into nucleus.
Natividad Alcorta-Sevillano +3 more
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