Results 31 to 40 of about 10,274 (232)
Mechanical Stiffness Controls Dendritic Cell Metabolism and Function
Cell Reports, 2021 Summary: Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly understood.
Mainak Chakraborty +25 more
doaj +1 more source
WormBook, 2006 Wild C. elegans and other nematodes live in dirt and eat bacteria, relying on mechanoreceptor neurons (MRNs) to detect collisions with soil particles and other animals as well as forces generated by their own movement. MRNs may also help animals detect bacterial food sources.
openaire +3 more sources
Cells, 2021 The magnitude of eosinophil mobilization into respiratory tissues drives the severity of inflammation in several airway diseases. In classical models of leukocyte extravasation, surface integrins undergo conformational switches to high-affinity states ...
Kiho Son +3 more
doaj +1 more source
Mechanosensing: A Regulation Sensation [PDF]
Current Biology, 2015 Mechanosensing of surfaces in bacteria is a process that often uses obstruction of flagellum rotation to trigger behaviors such as adhesion and surface-associated movement. In a recent publication, the PilY1 protein of Pseudomonas aeruginosa has been implicated as a novel mechanosensor that stimulates virulence in response to surface attachment.
Ellison, Courtney, Brun, Yves V.
openaire +2 more sources
Frontiers in Bioengineering and BiotechnologyWhile yes-associated protein (YAP) is now recognized as a potent mechanosensitive transcriptional regulator to affect cell growth and differentiation including the osteogenic transcription of mesenchymal stem cells (MSCs), most studies have reported the ...
Eunju Kim +7 more
doaj +1 more source
Noxious Mechanosensation [PDF]
, 2018 Abstract This article introduces a number of critical features of mechanical transduction and neuronal sensory coding, with particular reference to mechanical pain. High threshold mechanoreceptors (HTMRs) in skin are the first relay point for the transduction of noxious mechanical force into the nervous system, and their properties ...
Delmas, Patrick +2 more
openaire +2 more sources
Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease
BiomoleculesGlycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways.
Aikaterini Berdiaki +5 more
doaj +1 more source
Two-dimensional molecular condensation in cell signaling and mechanosensing
Acta Biochimica et Biophysica Sinica, 2023 Membraneless organelles (MLO) regulate diverse biological processes in a spatiotemporally controlled manner spanning from inside to outside of the cells.
Guo Xiangfu +4 more
doaj +1 more source
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Advanced Functional Materials, EarlyView.Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt +2 more
wiley +1 more source
Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering
Biomolecules, 2020 The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of ...
Gloria Garoffolo +5 more
doaj +1 more source