Results 51 to 60 of about 10,274 (232)

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

Advanced Materials, EarlyView.
This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar, Nghi Tran, Yu‐Chang Chen, Kang I. Ko, Rebecca G. Wells, Kyle H. Vining   +5 more
wiley   +1 more source

Mechanosensing tensile solid stresses [PDF]

Proceedings of the National Academy of Sciences, 2019
Experiments and modeling over the past decade have concluded that cells use sophisticated molecular “clutches” at focal adhesions to determine the stiffness of their supporting substrate (1). This mechanism has been shown to modulate a variety of cell functions, including differentiation and migration. In PNAS, Panzetta et al.
Lance L, Munn, Hadi T, Nia
openaire   +2 more sources

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Computational modelling to predict mechanosensing of fibroblast cells in response to different material properties [PDF]

, 2021
Wenjian Yang, Ma Luo, Yanfei Gao, Jinju Chen   +3 more
openalex   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Mechanobiology of Autophagy: The Unexplored Side of Cancer

Frontiers in Oncology, 2021
Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses.
Maria Paz Hernández-Cáceres, Leslie Munoz, Leslie Munoz, Javiera M. Pradenas, Javiera M. Pradenas, Francisco Pena, Francisco Pena, Pablo Lagos, Pablo Aceiton, Pablo Aceiton, Gareth I. Owen, Gareth I. Owen, Gareth I. Owen, Eugenia Morselli, Eugenia Morselli, Alfredo Criollo, Alfredo Criollo, Alfredo Criollo, Andrea Ravasio, Cristina Bertocchi   +19 more
doaj   +1 more source

Molecular mechanisms of cellular mechanosensing [PDF]

Nature Materials, 2013
Mechanical forces direct a host of cellular and tissue processes. Although much emphasis has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless be transmitted through the cortical cytoskeleton. Yet how the actin cortex senses and transmits forces and how cytoskeletal proteins interact in response to the forces is ...
Tianzhi Luo, Krithika Mohan, Pablo A. Iglesias, Douglas N. Robinson   +3 more
openaire   +2 more sources

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction

Frontiers in Cell and Developmental Biology, 2020
Mesenchymal stem cell (MSC) transplantation has demonstrated its potential in repairing infarct heart tissue and recovering heart function after myocardial infarction (MI).
Dan Zhu, Peng Wu, Peng Wu, Changchen Xiao, Wei Hu, Tongtong Zhang, Xinyang Hu, Wei Chen, Wei Chen, Jian’an Wang   +9 more
doaj   +1 more source

A Method Enabling Comprehensive Isolation of Arabidopsis Mutants Exhibiting Unusual Root Mechanical Behavior

Frontiers in Plant Science, 2021
Root penetration into soils is fundamental for land plants to support their own aboveground parts and forage water and nutrients. To elucidate the molecular mechanisms underlying root mechanical penetration, mutants defective in this behavior need to be ...
Hiroshi Tojo, Aki Nakamura, Ali Ferjani, Yusuke Kazama, Tomoko Abe, Hidetoshi Iida   +5 more
doaj   +1 more source