Results 71 to 80 of about 10,274 (232)
Filamins in Mechanosensing and Signaling [PDF]
Annual Review of Biophysics, 2012 Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors. By cross-linking and anchoring actin filaments, filamins stabilize the plasma membrane, provide cellular cortical ...
Ziba, Razinia +3 more
openaire +2 more sources
Cytoskeleton, EarlyView.ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source
Mechanophoric 3‐Arm Star Functional Block Copolymer Based on Rhodamine Derivative
Macromolecular Materials and Engineering, EarlyView.Mechanoresponsive rhodamine containing linear and star block and random copolymers were synthesized and characterized. All materials transitioned into a “switch‐on” state in the film form, but only the star block copolymer architecture exhibited a complete and precise peak shift upon stretching, providing new insights into the mechanochemical ...
Swadhin Chakraborty +8 more
wiley +1 more source
Vascular Mechanobiology: Towards Control of In Situ Regeneration
Cells, 2017 The paradigm of regenerative medicine has recently shifted from in vitro to in situ tissue engineering: implanting a cell-free, biodegradable, off-the-shelf available scaffold and inducing the development of functional tissue by utilizing the ...
Eline E. van Haaften +2 more
doaj +1 more source
Responsive Materials, EarlyView.This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of ...
Ruth M. C. Verbroekken +2 more
wiley +1 more source
Trpv4 Regulates Topography-Mediated Bone Formation Via Macrophage-Osteoclast Axis
International Dental JournalAim or purpose: Osteoinductive biomaterial hold great potentials in repairing segmental jaw bone defects. However, the mechanism behind remains unknown.
Jingqi Wu, Mingzheng Li
doaj +1 more source
Feeling Stressed or Strained? A Biophysical Model for Cell Wall Mechanosensing in Plants
Frontiers in Plant Science, 2019 Mechanical signals have recently emerged as a major cue in plant morphogenesis, notably influencing cytoskeleton organization, gene expression, protein polarity, or cell division. Although many putative mechanosensing proteins have been identified, it is
Antoine Fruleux +2 more
doaj +1 more source
Small, EarlyView.This work demonstrates a new thermophoretic strategy to fabricate fluorescently labeled stiffness gradient hydrogels, enabling contactless stiffness characterization. Fibroblasts cultured on gradient GelMA and Gellan gum hydrogels revealed distinct cell morphology and migration behavior.
Shin Wei Chong +8 more
wiley +1 more source
Emerging S100A11 roles: Regulation of focal adhesion dynamics and mechanosensing
Cell Structure and FunctionS100A11 is a small calcium-binding protein that has been studied in the context of growth regulation and membrane repair. However, it has recently been linked to the disassembly of focal adhesions.
Tareg Omer Mohammed +2 more
doaj +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source