Results 81 to 90 of about 10,274 (232)

Collagen and Its Roles in the Tumor Immune Microenvironment: Structure, Function, and Therapeutic Potential

Frontiers in Bioscience-Landmark
Collagen, the primary structural protein of the extracellular matrix, shows marked structure–function duality in the tumor immune microenvironment (TIME). Biomechanical and biophysical alterations—matrix stiffening, viscoelastic energy dissipation, fiber
Yinxin Zhang, Wenhui Wang, Guiyan Liu, Lili Wang, Xinkang Zhang, Jie Mei, Kai Yang   +6 more
doaj   +1 more source

A TICT-AIE Activated Dual-Channel Fluorescence-On Probe to Reveal the Dynamics Mechanosensing of Lipid Droplets During Ferroptosisa

, 2023
Ao Yu, Wei Zhang, qiangsheng zhang, Kunnan Yang, xiongbo liu, Hongtao Liu, Jialin Xie, Feng Yan, Jianwei Li, Chunman Jia   +9 more
openalex   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science
The secretory pathway is a sophisticated endomembrane machinery designed to transport and deliver proteins and lipids to intracellular organelles and the extracellular space.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. delMercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
doaj   +1 more source

Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load [PDF]

, 2021
Neil Ibata, Eugene M. Terentjev
openalex   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Author Correction: Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts [PDF]

, 2021
Cierra J. Walker, Claudia Crocini, Daniel Ramirez, Anouk R. Killaars, Joseph C. Grim, Brian A. Aguado, Stephen K. Clark, Mary A. Allen, Robin D. Dowell, Leslie A. Leinwand, Kristi S. Anseth   +10 more
openalex   +1 more source

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Tunable gelatin methacrylate polyethylene glycol diacrylate hydrogels for cell mechanosensing applications

Frontiers in Biomaterials Science
Three-dimensional (3D) tissue-engineered scaffolds mimic the physiological environment of cells by providing essential structural support, biochemical cues, and the mechanical strength needed for cell adhesion, proliferation, migration, and ...
Eya Ferchichi, Samuel Stealey, Paige Bogert, Silviya Petrova Zustiak   +3 more
doaj   +1 more source