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A Hierarchical Mechanotransduction System: From Macro to Micro
Advanced Science, 2023 Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating
Rong Cao +3 more
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Physiological Reviews, 2023 This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical stimuli and transduction of mechanical signals that result in the acute ...
M. Davis +3 more
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Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
Bone Research, 2023 In the synovial joint, mechanical force creates an important signal that influences chondrocyte behavior. The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pathways and culminates in changes in
Ning Wang +8 more
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Integrin-mediated mechanotransduction [PDF]
Journal of Cell Biology, 2016 Sun, Guo, and Fässler review the function and regulation of integrin-mediated mechanotransduction and discuss how its dysregulation impacts cancer progession.
Zhiqi Sun, Shengzhen S Guo, R. Fässler
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Periodontal cell mechanotransduction [PDF]
Open Biology, 2018 The periodontium is a structurally and functionally complex tissue that facilitates the anchorage of teeth in jaws. The periodontium consists of various cell types including stem cells, fibroblasts and epithelial cells.
Sasanka S. Chukkapalli, Tanmay P. Lele
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Flow-mediated endothelial mechanotransduction. [PDF]
Physiological Reviews, 1995 Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses occurs by the action of hemodynamic shear stresses on the endothelium.
P. Davies
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Mechanotransduction in Skin Inflammation
Cells, 2022 In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes.
Maria S. Shutova, Wolf-Henning Boehncke
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Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets [PDF]
MedCommCell mechanics is a fundamental regulator of numerous cellular processes, orchestrating critical biological activities spanning from embryogenesis to senescence.
Yicen Long +5 more
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The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives [PDF]
Frontiers in ImmunologyOrgan fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function.
Chao Lei +7 more
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Extracellular mechanotransduction [PDF]
Journal of General Physiology, 2022 We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Haller, Stephen J., Dudley, Andrew T.
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