Results 161 to 170 of about 43,729 (258)

Mechanobiology and mechanotransduction in propathological cellular system

, 2018
Cells and tissues respond to environmental forces transducing them into biochemical signals. This cellular property has induced a large interest in biomedical area to study the possibility of using cell (or tissue) mechanical properties (e.g., their stiffness) as a marker for early diagnosis of pathologies or as trigger point to modulate cell/tissue ...
openaire   +1 more source

Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling. [PDF]

Nat Commun
Liu X, Ye Y, Li Z, Liao L, Wei Q.
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Tumor microenvironment and mechanotransduction pathways: Novel targets and new directions for cancer therapy. [PDF]

Mechanobiol Med
Zhang X, Sun J, Li Z, Wang S.
europepmc   +1 more source

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Velocity sensitivity of mechanotransduction in the afferent terminal underlies vibration detection in the Pacinian corpuscle. [PDF]

Nat Commun
Chikamoto A, Meng M, Gracheva EO, Bagriantsev SN.   +3 more
europepmc   +1 more source

Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia

Clinical Genetics, EarlyView.
Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise, Benkirane‐Jessel Nadia, Anton Nicolas, Vandamme Thierry, Clauss François, Conzatti Guillaume   +5 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Effects of nanotopography on cell adhesion, morphology and differentiation [PDF]

, 2011
Dalby, M.J., Gadegaard, N., Oreffo, R.O.C., Tsimbouri, P.   +3 more
core  

Cardiac mechanotransduction from development to disease. [PDF]

APL Bioeng
Kim NY, Jo H, Becker C, Soicher I, Ni Y, Cho S, Kim H.   +6 more
europepmc   +1 more source