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Intranuclear Delivery of DNA Nanostructures via Cellular Mechanotransduction
Nano Letters, 2022DNA nanostructures are attractive gene carriers for nanomedicine applications, yet their delivery to the nucleus remains inefficient. We present the application of extracellular mechanical stimuli to activate cellular mechanotransduction for boosting the intranuclear delivery of DNA nanostructures.
Huize Li +6 more
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The role of microtopography in cellular mechanotransduction
Biomaterials, 2012Mechanotransduction is crucial for cellular processes including cell survival, growth and differentiation. Topographically patterned surfaces offer an invaluable non-invasive means of investigating the cell response to such cues, and greater understanding of mechanotransduction at the cell-material interface has the potential to advance development of ...
Laura E, McNamara +7 more
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Role of vinculin in cellular mechanotransduction
Cell Biology International, 2016AbstractCell–matrix adhesion and cell–cell contacts are essential for the metabolism, protein synthesis, survival, and cancer metastasis of cells. Major transmembrane receptors are the integrins, which are responsible for cell–matrix adhesions, and the cadherins, which are important for cell–cell adhesions.
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Review of cellular mechanotransduction on micropost substrates
Medical & Biological Engineering & Computing, 2015As physical entities, living cells can sense and respond to various stimulations within and outside the body through cellular mechanotransduction. Any deviation in cellular mechanotransduction will not only undermine the orchestrated regulation of mechanical responses, but also lead to the breakdown of their physiological function.
Yuxu, Geng, Zhanjiang, Wang
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2009
'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of ...
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'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of ...
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TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION
Annual Review of Physiology, 1997▪ Abstract Physical forces of gravity, hemodynamic stresses, and movement play a critical role in tissue development. Yet, little is known about how cells convert these mechanical signals into a chemical response. This review attempts to place the potential molecular mediators of mechanotransduction (e.g.
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Functional coupling of ion channels in cellular mechanotransduction
Biochemical and Biophysical Research Communications, 2014The major players in the processes of cellular mechanotransduction are considered to be mechanosensitive (MS) or mechano-gated ion channels. Non-selective Ca(2+)-permeable channels, whose activity is directly controlled by membrane stretch (stretch-activated channels, SACs) are ubiquitously present in mammalian cells of different origin.
Vladislav I, Chubinskiy-Nadezhdin +2 more
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Microengineering tools to study cellular mechanotransduction
Bio-, Micro-, and Nanosystems (IEEE Cat. No.03EX733), 2004Cells respond to many signals from their local environment, as a result of contact with solid-state surfaces, soluble agents, neighboring cells, and mechanical forces. We are investigating the interactions between these signals to understand how cells integrate the mechanical and biochemical signals in regulating endothelial cell function.
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Biomaterials for Studies in Cellular Mechanotransduction
2011The conversion of mechanical stimuli into chemical signals is of the utmost importance for developmental and normal physiology. Mechanotransduction plays a pivotal role in regulating cellular function and, subsequent tissue maintenance and repair, apoptosis, and many other physiological functions, coupled with a broad array of soluble factors.
Ross De Volder, Hyunjoon Kong
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Cellular Mechanisms of Mechanotransduction in Bone
2010Bone is a dynamic tissue that adjusts its structure over time to adapt to changes in mechanical load. This adaptive ability is critical to skeletal development and maintenance of optimal skeletal health throughout life. Imbalances in the ability of bone to keep pace with demands placed on it by mechanical loading results in bone that is fragile and ...
Suzanne R.L. Young, Fredrick M. Pavalko
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