Results 11 to 20 of about 39,386 (288)
Frontiers in Molecular Neuroscience, 2022 Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li +4 more
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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism.
Xingpeng Di +8 more
semanticscholar +1 more source
Journal of Orthopaedic Translation, 2021 Background: Osteocytes, composing over 90% of bone cells, are well known for their mechanosensing abilities. Aged osteocytes with impaired morphology and function are less efficient in mechanotransduction which will disrupt bone turnover leading to ...
Meng Chen Michelle Li +4 more
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Tuning immunity through tissue mechanotransduction
Nature reviews. Immunology, 2022 This Review considers how the biophysical properties of a tissue are able to shape immune cell function through the process of mechanotransduction. There are multiple mechanotransduction pathways that operate in immune cells and the authors highlight ...
Huixun Du +6 more
semanticscholar +1 more source
Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]
PLoS Genetics, 2010 Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore +4 more
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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Biophysical Reports, 2021 Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
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Advancement of science, 2023 The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are ...
Wenyan Xie +7 more
semanticscholar +1 more source
Brain and Behavior, 2023 Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes.
Qingcui Zheng +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Osteoarthritis is a global health problem that affects load-bearing joints, causing loss of mobility and enormous healthcare costs. However, disease-modifying approaches are lacking.
Whasil Lee +9 more
semanticscholar +1 more source
Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction.
Bioactive Materials, 2023 Osteoclasts ubiquitously participate in bone homeostasis, and their aberration leads to bone diseases, such as osteoporosis. Current clinical strategies by biochemical signaling molecules often perturb innate bone metabolism owing to the uncontrolled ...
Xiaogang Wang +3 more
semanticscholar +1 more source