Results 41 to 50 of about 39,386 (288)
The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Communications Biology, 2022 Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix (ECM).
D. Wilson, A. Tinker, Thomas Iskratsch
semanticscholar +1 more source
Mechanisms of Mechanotransduction [PDF]
Developmental Cell, 2006 Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of ...
Orr, A. Wayne +3 more
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Metavinculin modulates force transduction in cell adhesion sites
Nature Communications, 2020 Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop
Verena Kanoldt +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring.
Jiayi Yin +7 more
semanticscholar +1 more source
Mechanotransduction and fibrosis [PDF]
Journal of Biomechanics, 2014 Scarring and tissue fibrosis represent a significant source of morbidity in the United States. Despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development.
Dominik, Duscher +10 more
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New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction
Frontiers in Endocrinology, 2015 Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj +1 more source
Mechanotransduction in osteogenesis
Bone & Joint Research, 2020 Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and function of the cell, is described ...
Stewart, S +4 more
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Aging, Osteocytes, and Mechanotransduction [PDF]
Current Osteoporosis Reports, 2017 The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging ...
Hemmatian, Haniyeh +3 more
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Osteoarthritis and Cartilage Open, 2022 Objective: Exercise is known to induce beneficial effects in synovial joints. However, the mechanisms underlying these are unclear. Synovial joints experience repeated mechanical loading during exercise.
Alyssa K. Hahn +5 more
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Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion
Circulation Research, 2022 Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway ...
Dongwon Choi +24 more
semanticscholar +1 more source