Results 51 to 60 of about 39,386 (288)
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.
Annual Review of Neuroscience, 2020 Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit ...
P. Jin, L. Jan, Y. Jan
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Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction
Frontiers in Bioengineering and Biotechnology, 2019 Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due
Danahe Mohammed +8 more
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Cancer Cell, 2019 Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor cells with the ability to proliferate without restraint, to invade through ...
Jonathan M Cooper, F. Giancotti
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Mechanotransduction in mammalian sensory hair cells.
Molecular and cellular neurosciences, 2022 In the inner ear, the auditory and vestibular systems detect and translate sensory information regarding sound and balance. The sensory cells that transform mechanical input into an electrical signal in these systems are called hair cells.
G. A. Caprara, Anthony W. Peng
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Rat Merkel cells are mechanoreceptors and osmoreceptors. [PDF]
PLoS ONE, 2009 Merkel cells (MCs) associated with nerve terminals constitute MC-neurite complexes, which are involved in slowly-adapting type I mechanoreception. Although MCs are known to express voltage-gated Ca2+ channels and hypotonic-induced membrane deformation is
Nicholas Boulais +7 more
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Mechanotransduction in Mesenchymal Stem Cells (MSCs) Differentiation: A Review
International Journal of Molecular Sciences, 2022 Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating ...
Narmadaa Raman +4 more
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Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells
CellsExtracellular biophysical properties have particular implications for a wide spectrum of cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene expression, cell–matrix and cell–cell adhesion, and signal ...
C. Mierke
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Cellular Mechanotransduction: From Tension to Function
Frontiers in Physiology, 2018 Living cells are constantly exposed to mechanical stimuli arising from the surrounding extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes through which such physical cues are transformed into a biological response
Fabiana Martino +4 more
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Physics of mechanotransduction by Piezo ion channels
The Journal of General Physiology, 2022 Young et al. review and synthesize the mechanistic principles of forces and energies involved in Piezo ion channel mechanotransduction.
M. Young, A. Lewis, J. Grandl
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Stem Cells International, 2020 Bone marrow-derived mesenchymal stromal cells (hMSCs) are capable of differentiating into the osteogenic lineage, and for osteogenic differentiation, mechanical loading is a relevant stimulus.
Sigrid Müller-Deubert +7 more
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