Results 1 to 10 of about 56,603 (238)

Calculation of the Median Lethal Dose and Low Lethal Dose Using the CombiStats Biometric Software

Регуляторные исследования и экспертиза лекарственных средств, 2021
The median lethal dose (LD50) and low lethal dose (LD10) are calculated in acute toxicity studies, as well as during specific activity assessment of some medicines.
P. V. Shadrin, T. A. Batuashvili, L. V. Simutenko, N. P. Neugodova   +3 more
doaj   +3 more sources

Organoleptic assessment and median lethal dose determination of oral aldicarb in rats. [PDF]

Ann N Y Acad Sci, 2020
AbstractAldicarb, a carbamate pesticide, is an acetylcholinesterase inhibitor, with oral median lethal dose (LD50) estimates in rats ranging from 0.46 to 0.93 mg/kg. A three‐phase approach was used to comprehensively assess aldicarb as an oral‐ingestion hazard. First, the solubility of aldicarb in popular consumer beverages (bottled water, apple juice,
Rice NC, Rauscher NA, Moffett MC, Myers TM.   +3 more
europepmc   +4 more sources

The new algorithm for calculation of median lethal dose (LD50) and effective dose fifty (ED50) of Micrarus fulvius venom and anti-venom in mice [PDF]

International Journal of Veterinary Science and Medicine, 2016
One million people throughout the world are bitten yearly by poisonous snakes. Of this, one-tenth died and three-tenth suffer some forms of disabilities.
Saganuwan Alhaji Saganuwan
doaj   +2 more sources

Determination of the median lethal dose of indoxacarb pesticide in Wistar rat [PDF]

Journal of Veterinary and Animal Sciences, 2023
Indoxacarb is a novel organophosphate substitute and is considered a “lower risk” pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked to substantial health problems.
Archana Raj, N. Suresh Nair, A.R. Nisha, S. Sujith, C. Divya , R. Shankar   +5 more
doaj   +2 more sources

Median lethal Dose and Acute Toxicity of Rosa canina L: In-Vivo Study

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Rosa canina belongs to rosacea family. Rosa. canina has a high concentration of phyto-constituents such as flavonoids, carotenoids, triterpene and vitamins as vitamin C, E, and A Rosa canina have an anti-inflammatory and antioxidant   effects. The
Zaman Mahmood Jasim, Ghaith Ali Jasim, Ibrahim Saleh Abbas   +2 more
doaj   +2 more sources

Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract [PDF]

Molecules, 2010
The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes ...
Abdulelah H. Al-Adhroey, Zurainee M. Nor, Rohela Mahmud, Hesham M. Al-Mekhlafi   +3 more
doaj   +2 more sources

Determination of median lethal dose of combination of endosulfan and cypermethrin in wistar rat.

Toxicol Int, 2013
The present study was designed to determine the lethal dose 50 (LD50) of combination of cypermethrin, a pyrethroid, and endosulfan, an organochlorine compound in Wistar rats. LD50 is the amount (dose) of a chemical, calculated as per the concentration of chemicals that produces death in 50% of a population of test animals to which it is administered by
Raj J, Chandra M, Dogra TD, Pahuja M, Raina A.   +4 more
europepmc   +4 more sources

Determination of the median lethal dose of zinc gluconate in mice and safety evaluation. [PDF]

BMC Pharmacol Toxicol
Abstract Background Zinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous injection and the safety evaluation of animal models for ZG. This study aims to determine the safe dose range of ZG for intravenous injection in C57BL/6J mice.
Wang YC, Yang X, Xiao J, Wei SM, Su Y, Chen XQ, Huang T, Shan QW.   +7 more
europepmc   +3 more sources

Determination of the Median Lethal Dose and Electrophoretic Pattern of Hottentotta saulcyi (Scorpiones, Buthidae) Scorpion Venom [PDF]

Journal of Arthropod-Borne Diseases, 2015
Background: In this study, we investigated the lethal potency, electrophoretic protein pattern and in vivo effects of Hottentotta saulcyi scorpion venom in mice. Methods: Scorpions were collected at night, by using a UV lamp from Mardin Province, Turkey.
ErsenAydın Yağmur, Özcan Özkan, KZafer Karaer   +2 more
doaj   +1 more source

Estimating the Median Lethal Dose of Breast Cancer with Modified Weibull Statistical Model

Ibn Al-Haitham Journal for Pure and Applied Sciences
        In this paper, based on a linear relationship between the natural logarithms of the scale parameter and dose, nineteen models are constructed using the modified Weibull statistical model to describe the relationship of dose-response and time ...
Nadia H. Al-Noor, Iden Hasan Hussein, Shaima Abbas Jasim   +2 more
doaj   +2 more sources