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Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
Blood Science, 2021 . Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases; however, the details of the mechanism leading to low platelet count remain elusive.
Brian Eyden +4 more
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CD34 and CD79a immunopositivity in megakaryocytes
Human Pathology: Case Reports, 2021 CD34 and CD79a are markers of hematopoietic stem cell and B-lymphoid cells, respectively. The abnormal expression of these markers in megakaryocytes has been noticed in cases of myelodysplastic syndrome, inherited platelet disorders, and reactive ...
Pavithra Ayyanar +3 more
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Frontiers in Bioscience-Landmark, 2022 Platelets are small, anucleate cellular fragments, which are produced by megakaryocytes, and play a key role in hemostasis and thrombus formation. The differentiation of megakaryocytes from hematopoietic stem cells in bone marrow and the development of ...
Li Li +10 more
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Frontiers in Oncology, 2020 Numerous studies have documented ultrastructural abnormalities in malignant megakaryocytes from bone marrow (BM) of myelofibrosis patients but the morphology of these cells in spleen, an important extramedullary site in this disease, was not investigated
Maria Zingariello +8 more
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Technology in Cancer Research & Treatment, 2023 The evaluation of megakaryocytes is an important part of the work up on bone marrow smear examination. It has significance in the differential diagnosis, therapeutic efficacy assessment, and predication of prognosis of many hematologic diseases.
Xiaofen Wang MM +7 more
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Lipid composition and metabolism in megakaryocytes at different stages of maturation.
Journal of Lipid Research, 1990 The lipid composition and metabolism of isolated guinea pig megakaryocyte subgroups at various stages of maturation were investigated. Three groups were studied: 1) 67% of megakaryocytes in Group A were immature; 2) Group B was heterogeneous and ...
PK Schick, K Williams-Gartner, XL He
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RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. [PDF]
PLoS ONE, 2013 RhoA plays a multifaceted role in platelet biology. During platelet development, RhoA has been proposed to regulate endomitosis, proplatelet formation, and platelet release, in addition to having a role in platelet activation.
Aae Suzuki +11 more
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Pharmacological Research - Modern Chinese Medicine, 2023 Backgrounds: The Qing-Fei-Pai-Du Decoction (QFPDD) was reported to ameliorate the inflammatory coagulopathy and thrombocytopenia in COVID-19 patients. This work investigated the effects of QFPDD in endotoxaemia rats and then further studied its influence
Jiao Wu +5 more
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Human Pathology Reports, 2023 We report a patient with chronic immune thrombocytopenia purpura who underwent bone marrow biopsies before and after treatment with romiplostim. The biopsy after treatment with romiplostim showed a marked increase in the numbers of megakaryocytes which ...
Charles M. Lombard +2 more
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Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint
Haematologica, 2016 Megakaryocytes are naturally polyploid cells that increase their ploidy by endomitosis. However, very little is known regarding the mechanism by which they escape the tetraploid checkpoint to become polyploid.
Anita Roy +11 more
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