Results 31 to 40 of about 47,257 (190)

The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia

Clinical and Applied Thrombosis/Hemostasis, 2022
Objective: To investigate the application value of bone marrow megakaryocyte count, the proportion of megakaryocytes at each stage, and the platelet parameter in the clinical diagnosis of primary immune thrombocytopenia (ITP).
Weiwei Wang MS, Shuan Tao MS, Xia Zhang MS, Weiguo Wang MS, Yuanhong Xu PhD, Wei Liang PhD   +5 more
doaj   +1 more source

CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

eLife, 2022
Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow.
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao   +7 more
doaj   +1 more source

Decoding Human Megakaryocyte Development [PDF]

Cell Stem Cell, 2021
Despite our growing understanding of embryonic immune development, rare early megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA sequencing of human MKs from embryonic yolk sac (YS) and fetal liver (FL) to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis.
Hongtao, Wang, Jian, He, Changlu, Xu, Xiaoyuan, Chen, Hua, Yang, Shujuan, Shi, Cuicui, Liu, Yang, Zeng, Dan, Wu, Zhijie, Bai, Mengge, Wang, Yuqi, Wen, Pei, Su, Meijuan, Xia, Baiming, Huang, Chunyu, Ma, Lihong, Bian, Yu, Lan, Tao, Cheng, Lihong, Shi, Bing, Liu, Jiaxi, Zhou   +21 more
openaire   +2 more sources

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

Blood Advances, 2017
: Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche is critical for stem cell function and maintenance of the stem cell pool.
Safa F. Mohamad, Linlin Xu, Joydeep Ghosh, Paul J. Childress, Irushi Abeysekera, Evan R. Himes, Hao Wu, Marta B. Alvarez, Korbin M. Davis, Alexandra Aguilar-Perez, Jung Min Hong, Angela Bruzzaniti, Melissa A. Kacena, Edward F. Srour   +13 more
doaj   +1 more source

Changes in Megakaryocytes in Cases of Thrombocytopenia: Bone Marrow Aspiration and Biopsy Analysis [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Thrombocytopenia (platelet counts less than 150,000/μl) is commonly encountered in various hematological disorders including myelodysplastic syndromes as well as various non-myelodysplastic hematological conditions.
Tejinder Singh Bhasin, Sonam Sharma, Mridu Manjari, Rahul Mannan, Vandana Kansal, Manish Chandey, Sanjay Piplani   +6 more
doaj   +1 more source

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice

Frontiers in Pharmacology, 2021
Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Ka Bian, Yuling Wang, Xuexue Xu, Shuwen Wu, Kun Cheng, Yun Zhang, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +13 more
doaj   +1 more source

Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture

Cellular Physiology and Biochemistry, 2015
Background/Aims: Salicylate causes drug-induced immune thrombocytopenia. However, some clinical studies indicate the presence of additional mechanisms in the drug-induced thrombocytopenia, by which the platelet production from megakaryocytes may directly
Itsuro Kazama, Asuka Baba, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Masahiro Tachi   +6 more
doaj   +1 more source

The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1low Mice

Frontiers in Oncology, 2022
A major role for human (h)CXCL8 (interleukin-8) in the pathobiology of myelofibrosis (MF) has been suggested by observations indicating that MF megakaryocytes express increased levels of hCXCL8 and that plasma levels of this cytokine in MF patients are ...
Paola Verachi, Francesca Gobbo, Francesca Gobbo, Fabrizio Martelli, Andrea Martinelli, Giuseppe Sarli, Andrew Dunbar, Andrew Dunbar, Ross L. Levine, Ross L. Levine, Ross L. Levine, Ronald Hoffman, Maria Teresa Massucci, Laura Brandolini, Cristina Giorgio, Marcello Allegretti, Anna Rita Migliaccio, Anna Rita Migliaccio   +17 more
doaj   +1 more source