Results 41 to 50 of about 47,257 (190)
Platelets, Not an Insignificant Player in Development of Allergic Asthma
Cells, 2021 Allergic asthma is a chronic and heterogeneous pulmonary disease in which platelets can be activated in an IgE-mediated pathway and migrate to the airways via CCR3-dependent mechanism.
Liping Luo +3 more
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Cold Spring Harbor Perspectives in Medicine, 2019 Acute megakaryoblastic leukemia (AMKL) is a rare malignancy affecting megakaryocytes, platelet-producing cells that reside in the bone marrow. Children with Down syndrome (DS) are particularly prone to developing the disease and have a different age of onset, distinct genetic mutations, and better prognosis as compared with individuals without DS who ...
Maureen, McNulty, John D, Crispino
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A comparison of haematopoietic stem cells from umbilical cord blood and peripheral blood for platelet production in a microfluidic device [PDF]
, 2019 Background and objectives: Several sources of haematopoietic stem cells have been used for static culture of megakaryocytes to produce platelets in vitro.
Baruch, Dominique +5 more
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3 tera-basepairs as a fundamental limit for robust DNA replication [PDF]
, 2020 10 p.-2 tab.In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly ...
Al Mamun, M. +3 more
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Histology and histopathology, 1999 We reviewed the literature concerning the history of determination of the ploidy of human megakaryocytes and its relationship with diseases. The ploidy of rabbit megakaryocytes was analyzed by microspectrophotometry in 1964, and the analysis of the ploidy in human megakaryocytes was first performed in 1968. Presently, microphotometry and flow cytometry
Kobayashi, Y., Kondo, M.
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Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 [PDF]
, 2018 Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of childhood precursor B-cell acute lymphoblastic leukemia.
Bashton, Matthew +18 more
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Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy [PDF]
, 2016 Acknowledgments Blood biochemistry analysis and serum analysis were performed by the Easter Bush Pathology Department, University of Edinburgh. Animal husbandry was performed by Centre for Integrative Physiology bio-research restructure technical staff ...
Azzouz, Mimoun +15 more
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Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood
Haematologica, 2019 Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems.
Seema Bhatlekar +10 more
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Mechanisms of thrombocytopenia in platelet-type von Willebrand disease
Haematologica, 2019 Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction.
Loredana Bury +5 more
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