Results 61 to 70 of about 47,257 (190)

Megakaryocytes in Bone Metastasis: Protection or Progression?

Cells, 2019
Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain ...
Paola Maroni
doaj   +1 more source

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

A subset of megakaryocytes regulates development of hematopoietic stem cell precursors

The EMBO Journal
Understanding the regulatory mechanisms facilitating hematopoietic stem cell (HSC) specification during embryogenesis is important for the generation of HSCs in vitro.
Wenlang Lan, Jinping Li, Zehua Ye, Yumin Liu, Sifan Luo, Xun Lu, Zhan Cao, Yifan Chen, Hongtian Chen, Zhuan Li   +9 more
doaj   +1 more source

A megakaryocyte in the peripheral blood: evidence for pulmonary migration?

Frontiers in Hematology
Pulmonary megakaryocytes were first identified over a century ago, but their origin is still debated. Two rare images of circulating megakaryocytes are presented to illustrate this discussion: The first shows an intact megakaryocyte with abundant ...
Stephanie Juané Kennedy, Stephanie Juané Kennedy   +1 more
doaj   +1 more source

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. [PDF]

, 1985
We have previously characterized a monoclonal antibody, S12, that binds only to activated platelets (McEver, R.P., and M.N. Martin, 1984, J. Biol. Chem., 259:9799-9804). It identifies a platelet membrane protein of Mr 140,000, which we have designated as
Bainton, DF, Jacques, YV, McEver, RP, Shuman, MA, Stenberg, PE   +4 more
core   +1 more source

Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]

, 2008
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Altmann, Frank, Amann, Barbara, Deeg, Cornelia A., Hauck, Stefanie M., Pompetzki, Dirk, Raith, Albert, Schmalzl, Thomas, Stangassinger, Manfred, Ueffing, Marius   +8 more
core   +1 more source

Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis

Platelets
Transcription factor 3 (TCF3) is a DNA transcription factor that modulates megakaryocyte development. Although abnormal TCF3 expression has been identified in a range of hematological malignancies, to date, it has not been investigated in myelofibrosis ...
Ryan J Collinson, Lynne Wilson, Darren Boey, Zi Yun Ng, Bob Mirzai, Hun S Chuah, Rebecca Howman, Carolyn S Grove, Jacques A J Malherbe, Michael F Leahy, Matthew D Linden, Kathryn A Fuller, Wendy N Erber, Belinda B Guo   +13 more
doaj   +1 more source

PLATELET TURNOVER AND ATHEROTHROMBOSIS

Атеротромбоз, 2017
Platelets play an important role in initiating atherothrombosis, i.e. the formation of blood clots inside a blood vessel at areas of atherosclerotic vascular injury.
A. V. MAZUROV
doaj   +1 more source

Severe Case of Peripheral Leukocytosis Initially Diagnosed as Myelodysplastic Syndrome/Myeloproliferative Neoplasm, Unclassifiable, but Possibly Prefibrotic Primary Myelofibrosis [PDF]

, 2014
Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD). A 74-year-old woman was admitted to our hospital for tarry stools, anemia, and marked peripheral leukocytosis of 1.4×105/μL ...
Hiramatsu, Yasushi, Kasahara, Akinori, Kondo, Eisei, Matsumura, Tadashi, Noguchi, Toshio, Ota, Seisuke, Takada, Saimon, Tanimoto, Mitsune, Umena, Sachio   +8 more
core   +1 more source

Non-specific binding of antibodies in immunohistochemistry: Fakes and facts [PDF]

, 2011
Protocols for blocking non-specific antibody (Ab) binding in immunohistochemistry are based on rather contradictory and outdated reports. This prompted us to prove, whether non-specific Ab binding may really lead to unwanted background staining in ...
Igor Buchwalow, Markus Tiemann, Vera Samoilova, Werner Boecker   +3 more
core   +1 more source