Results 71 to 80 of about 47,257 (190)

Inherited thrombocytopenias—recent advances in clinical and molecular aspects

Platelets, 2017
Since the beginning of the century, our knowledge of inherited thrombocytopenias greatly advanced, and we presently know 30 forms with well-defined genetic defects.
Carlo L. Balduini, Federica Melazzini, Alessandro Pecci   +2 more
doaj   +1 more source

Modern concepts of the platelet in health and disease [PDF]

, 1962
Thesis (M.D.)--Boston ...
Estes, J. Worth
core  

Acquired pure megakaryocytic aplasia successfully treated with cyclosporine [PDF]

, 2010
Acquired pure megakaryocytic aplasia is a rare hematological disorder characterized by thrombocytopenia with absent or markedly reduced megakaryocytes in the bone marrow.
Aisha Al Khinji, Firyal Ibrahim, Halima El Omri, Hanadi El Ayoubi, Hussein Baden, Ibrahim Al Hijji, Mohammed Yassin, Riham Hassan Negm, Ruba Yasin Taha   +8 more
core   +2 more sources

Circulating thrombopoietin levels in normal healthy blood donors and in aplastic anemia patients in relation to disease severity

Asian Journal of Transfusion Science, 2015
Background: Thrombopoietin (TPO) is the key hematopoietic growth factor regulating the production of platelets from bone marrow megakaryocytes and maintaining platelet hemostasis.
Abhay Singh, Anupam Verma, Soniya Nityanand, Rajendra Chaudhary, Priti Elhence   +4 more
doaj   +1 more source

Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3. [PDF]

, 2008
Systemic mastocytoses represent neoplastic proliferations of mast cells. In about 20% of cases systemic mastocytoses are accompanied by clonal haematopoietic non-mast cell-lineage disorders, most commonly myeloid neoplasms.
Dirnhofer, S., Horny, H.-P., Jotterand, M., Muhlematter, D., Sotlar, Karl, Theocharides, A., Tzankov, A., Went, P.   +7 more
core   +1 more source

Research progress of megakaryocytes and platelets in lung injury

Annals of Medicine
The lung is an important site of extramedullary platelet formation, and megakaryocytes in the lung participate in immune responses in addition to platelet production.
Tianzhen Hua, Guangliang Zhang, Yi Yao, Haoran Jia, Wei Liu   +4 more
doaj   +1 more source

Long-term human hematopoiesis in the SCID-hu mouse. [PDF]

, 1990
Coimplantation of small fragments of human fetal thymus and fetal liver into immunodeficient SCID mice resulted in the formation of a unique structure (Thy/Liv).
Kaneshima, H, McCune, Joseph, Namikawa, R, Weilbaecher, K, Yee, E   +4 more
core  

Interactions between megakaryocytes and tumour cells in the bone marrow vascular stem cell niche promote tumour growth and metastasis

, 2010
Specialized bone marrow microenvironments (vascular and osteoblastic 'niches') regulate normal haematopoietic stem/progenitor cells. Recently, the vascular niche has also been implicated as an area for preferential engraftment of malignant cells.
Psaila, Bethan, Psaila, Bethan
core   +1 more source

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]

, 2009
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny, K K Reichard, K Sotlar, M K Foucar, S A McClintock-Treep   +4 more
core   +1 more source

Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells

Scientific Reports
Suppression of human megakaryocytes by dengue virus (DENV) infection significantly reduces the platelet count that eventually leads to thrombocytopenia, severe dengue and death.
Swarnendu Basak, Shovan Dutta, Supreet Khanal, Girish Neelakanta, Hameeda Sultana   +4 more
doaj   +1 more source