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Prolonged Mitogen-Activated Protein Kinase Kinase (MEK) Inhibition Induces Increase in Proteolysis and Compensatory Phosphorylation of MEK and Protein Kinase B (AKT) in Plexiform Neurofibroma Cells [PDF]
CellsPlexiform neurofibromas associated with neurofibromatosis type I (pNF1s) are benign tumors caused by the complete loss of function of the NF1 gene, which encodes a negative regulator of the RAS/mitogen-activated protein kinase (MAPK) pathway. pNF1s carry
Kyungmin Ji +3 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Emilien Loeuillard, PhD +2 more
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Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation
Proceedings of the National Academy of Sciences, 2021 Significance Drugs that inhibit specific kinases now represent one of the main classes of targeted therapies. A majority of drug development efforts in this space focus on a given kinase in isolation as the target. However, our work demonstrates that in the context of the RAF/MEK/ERK pathway, the relevant target for compounds developed as ...
Gonzalo L. Gonzalez-Del Pino +5 more
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Protective effect of garlic on methyl ethyl ketone-induced biochemical changes in male rabbits. [PDF]
Journal of Bioscience and Applied Research, 2016 The present study evaluated the effect of inhalation of methyl ethyl ketone (MEK) on biochemical parameters of rabbits and the possible protective role of garlic aqueous extract. Animals were divided into 4 groups.
Zuhair Y. Al-Sahhaf
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Plants, 2020 Jerusalem artichoke (JA) is widely known to have inulin-rich tubers. However, its fresh aerial biomass produces significant levels of leaf protein and economic bioactive phytochemicals.
László Kaszás +9 more
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Manufacturing bioinspired flexible materials using ultrasound directed self-assembly and 3D printing
Materials & Design, 2020 Biological materials that are composed of hierarchical microstructures embedded in a matrix material can display enhanced mechanical or material properties compared to an unstructured mixture of the same constituent materials.
Paul Wadsworth +4 more
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Agronomy, 2020 Brown juice is a byproduct of fractionated green biomass during leaf protein isolation. It represents approximately 45%−50% of the total pressed fresh biomass.
Nóra Bákonyi +11 more
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Agronomy, 2020 Fertilization management is a key issue in plant nutrition to produce plants with good quality and quantity. Deproteinized leaf juice or brown juice (BJ) is a by-product during the isolation of leaf protein from biomass crops such as alfalfa. The idea of
Szilvia Kisvarga +9 more
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Acta Pharmaceutica, 2023 This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively ...
Liu Rui +4 more
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Galectin-3 regulates proliferation of glomerular mesangial cells under high glucose condition
Di-san junyi daxue xuebao, 2020 Objective To investigate the effect and underlying mechanism of galectin-3 (Gal-3) on the proliferation of mesangial cells (MCs) cultured under high glucose condition.
LIN Ziyue, ZHANG Panyang, CHONG Xinyu
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