Results 111 to 120 of about 79,654 (277)

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

open access: yesPhotochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza   +4 more
wiley   +1 more source

Childhood Obesity and Familial Hypercholesterolemia: Genetic Diseases that Contribute to Cardiovascular Disease [PDF]

open access: yes, 2014
Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency.
Caudle, Alyssa
core   +1 more source

Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]

open access: yes, 2009
Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Bekel, A.   +9 more
core   +3 more sources

The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and Activates Pomc Expression in the Developing Hypothalamus

open access: yesJournal of Neuroscience, 2019
Food intake is tightly regulated by a group of neurons present in the arcuate nucleus of the hypothalamus, which release Pomc-encoded melanocortins, the absence of which induces marked hyperphagia and early-onset obesity.
Daniela P. Orquera   +5 more
semanticscholar   +1 more source

TBX3‐ Related Disorder

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 291-299, February 2026.
ABSTRACT Heterozygous pathogenic variants in TBX3 cause Ulnar‐Mammary syndrome (UMS). The phenotype is classically characterized by upper limb defects, apocrine/mammary gland hypoplasia, hypogonadism, and various midline defects. However, the clinical spectrum is highly variable, and some individuals may present with a mild or atypical presentation ...
Ziv Halperin, Karin Weiss
wiley   +1 more source

5-HT obesity medication efficacy via POMC activation is maintained during aging [PDF]

open access: yes, 2014
Peer reviewedPublisher ...
Billups, Brian   +10 more
core   +3 more sources

Circadian adaptations to meal timing: Neuroendocrine mechanisms

open access: yesFrontiers in Neuroscience, 2013
Circadian rhythms of behavior and physiology are generated by central and peripheral circadian oscillators entrained by periodic environmental or physiological stimuli.
Danica F Patton, Ralph E Mistlberger
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota

open access: yesObesity, Volume 34, Issue 2, Page 372-381, February 2026.
ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Jane Shearer   +7 more
wiley   +1 more source

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system.

open access: yesJournal of Clinical Investigation, 2019
Glial cells have emerged as key players in the central control of energy balance and etiology of obesity. Astrocytes play a central role in neural communication via the release of gliotransmitters.
K. Bouyakdan   +13 more
semanticscholar   +1 more source

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