Results 11 to 20 of about 79,654 (277)
Melanocortin 1 Receptor: Structure, Function, and Regulation
Frontiers in Genetics, 2016 The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Mary C Boulanger, John D'Orazio
exaly +4 more sources
Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort
Nature Medicine, 2021 Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development.
Kaitlin H Wade +2 more
exaly +2 more sources
The melanocortin action is biased toward protection from weight loss in mice
Nature Communications, 2023 The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity.
Hongli Li +11 more
doaj +2 more sources
Cells, 2023 The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory ...
Antonietta Gerarda Gravina +10 more
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The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia
Science Translational Medicine, 2021 Pharmacological manipulation of the melanocortin-3 receptor bidirectionally controls feeding, providing a therapeutic target for eating disorders. An agonist against anorexia The eating disorder anorexia nervosa is potentially fatal but also poorly ...
, Jose Maldonado, Pauline Lining Pan
exaly +2 more sources
Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging [PDF]
Molecular MetabolismObjective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung +6 more
doaj +2 more sources
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]
Nature CommunicationsThe melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail +15 more
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Melanocortin Regulation of Inflammation
Frontiers in Endocrinology, 2019 Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system.
Wei Wang +3 more
doaj +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance This study expands understanding of opsin 3 (OPN3) function and of skin pigmentation. The findings presented here reveal that the nonvisual OPN3 modulates the pigmentation of human epidermal melanocytes—the melanin-producing cells of the ...
Lauren E Olinski +2 more
exaly +2 more sources
POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons [PDF]
eLifeInactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice.
Rajae Talbi +11 more
doaj +2 more sources