Results 21 to 30 of about 79,654 (277)

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Frontiers in Medicine, 2019
Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in
Anna Elizabeth Moscowitz, Huda Asif, Laurence Baily Lindenmaier, Andrew Calzadilla, Chongxu Zhang, Mehdi Mirsaeidi, Mehdi Mirsaeidi   +6 more
doaj   +2 more sources

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Giles Sh Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert   +2 more
exaly   +2 more sources

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

Cell Research, 2021
Shanshan, Antao Dai, Wanchao Yin
exaly   +2 more sources

Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord

Research Results in Pharmacology
Introduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda , Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto   +11 more
doaj   +3 more sources

Evidence for an interaction between cannabinoidergic and dopaminergic systems with melanocortin MC3/ MC4 receptors in regulating food intake of neonatal chick [PDF]

The Iranian Journal of Veterinary Science and Technology, 2021
The current study aimed to see how the central dopaminergic and cannabinoidergic mechanisms affect melanocortin-induced food intake in the neonatal layer chickens. In this regard, 9 experiments were designed. In experiment 1, chicks injected with control
Mohammad Bameri, Morteza Zendedel kheybari, Bita Vazir, Ahmad Asghari, Negar Panahi   +4 more
doaj   +1 more source

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

Cell, 2019
Agatha A Van Der Klaauw, Sophie Croizier, Lukas K J Stadler   +2 more
exaly   +2 more sources

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Molecular Metabolism, 2017
Tinh-Hai Collet, Jacek Mokrosiński, Edson M De Oliveira   +2 more
exaly   +2 more sources

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans

Frontiers in Immunology, 2023
IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model.
John Dodd, Robert Jordan, Marie Makhlina, Keith Barnett, Ad Roffel, Carl Spana, Alison Obr, Priyanka Dhingra, Paul S. Kayne   +8 more
doaj   +1 more source

A critical update on the leptin‐melanocortin system

Journal of Neurochemistry, 2023
The discovery of leptin in 1994 was an “eureka moment” in the field of neurometabolism that provided new opportunities to better understand the central control of energy balance and glucose metabolism. Rapidly, a prevalent model in the field emerged that
Olivier Lavoie, N. Michael, Alexandre Caron   +2 more
semanticscholar   +1 more source