Results 41 to 50 of about 79,654 (277)

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]

, 2015
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M., Herman, James P., Holland, Jenna, Morano, Rachel, Ottaway, Nickki, Perez-Tilve, Diego, Pressler, Joshua W., Sandoval, Darleen A., Seeley, Randy J., Sorrell, Joyce, Woods, Stephen C.   +10 more
core   +2 more sources

Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding

Science, 2020
Some calcium is required for binding The melanocortin-4 receptor (MC4R) coordinates food intake and energy expenditure and is a target for treating obesity.
Jing Yu, L. E. Gimenez, C. C. Hernandez, Yiran Wu, A. H. Wein, G. Han, K. McClary, S. Mittal, K. Burdsall, B. Stauch, Lijie Wu, S. N. Stevens, A. Peisley, Savannah Y. Williams, Valerie Chen, G. Millhauser, Suwen Zhao, R. Cone, R. Stevens   +18 more
semanticscholar   +1 more source

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

Nucleus Accumbens MC4-R Stimulation Reduces Food and Ethanol Intake in Adult Rats Regardless of Binge-Like Ethanol Exposure during Adolescence

Frontiers in Behavioral Neuroscience, 2017
The melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that melanocortin 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses and reduces ethanol consumption and ethanol ...
Francisca Carvajal, José M. Lerma-Cabrera, José M. Lerma-Cabrera, Manuel Alcaraz-Iborra, Montserrat Navarro, Todd E. Thiele, Inmaculada Cubero, Inmaculada Cubero   +7 more
doaj   +1 more source

Targeting central melanocortin receptors: a promising novel approach for treating alcohol abuse disorders

Frontiers in Neuroscience, 2014
The melanocortin (MC) peptides are produced centrally by propiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus and act through five seven-transmembrane G-protein coupled melanocortin receptor (MCR) subtypes.
Jeffrey eOlney, Montserrat eNavarro, Todd Eric Thiele   +2 more
doaj   +1 more source

Agouti overexpression in a transgenic model regulates integrity, permeability and electrogenic amino acid transport in zebrafish intestine

Frontiers in Marine Science, 2022
Overexpression of asip1 in transgenic zebrafish disrupts dorsoventral pigment pattern in addition to increasing food intake levels and linear growth. A higher feed intake is unnecessary in transgenic fish to enable larger and heavier growth.
Esther Leal, Anna Rita Angotzi, Alejandra Godino-Gimeno, Silvia F. Gregório, Josep Rotllant, Alfonso Saera-Vila, Juan Fuentes, José Miguel Cerdá-Reverter   +7 more
doaj   +1 more source

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases

Frontiers in Pharmacology, 2019
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana, Andrew W. Taylor, David G. Yee, Marie Makhlina, Wei Yang, John Dodd   +5 more
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Neurobiology of inflammation-associated anorexia

Frontiers in Neuroscience, 2010
Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system.
Laurent Gautron, Sophie Laye
doaj   +1 more source