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Melanocytes and Their Diseases [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Human melanocytes are distributed not only in the epidermis and in hair follicles but also in mucosa, cochlea (ear), iris (eye), and mesencephalon (brain) among other tissues. Melanocytes, which are derived from the neural crest, are unique in that they produce eu-/pheo-melanin pigments in unique membrane-bound organelles termed melanosomes, which can ...
Vincent J. Hearing, Yuji Yamaguchi
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Cancer, 1988 The clinical, histopathologic, immunohistochemical, and electron microscopic findings of two cases of melanocytic schwannoma are reported. One case, which occurred in the parotid gland, is believed to be the first reported in this location. The other case was located in the sacral spinal region.
Roberta M. Killeen +2 more
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The biology of melanocyte and melanocyte stem cell [PDF]
Acta Biochimica et Biophysica Sinica, 2014 The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations.
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Melanocytes and Skin Immunity [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2015 Melanocytes in skin are melanin-producing cells that are derived from the neural crest. They migrate during embryological development and localize in the epidermis and hair follicles where they pigment skin and hair (Nishimura, 2011). Melanocytes and their production of melanin pigment (a process termed melanogenesis) have important roles in cutaneous ...
Xing-Hua Gao +3 more
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Journal of Investigative Dermatology, 1979 Choroidal melanocytes of the eyes of postnatal animals are classified as postmitotic terminally differentiated cells. They have specific granules, the melanosomes, which undergo changes qualitatively and quantitatively correlated to the animal's increasing age.
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Biology of melanocytes in mammals
Frontiers in Cell and Developmental Biology, 2023 Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessing a dendritic morphology. These cells migrate to the epidermis and follicles, contributing to skin and hair pigmentation during embryonic development.
Ying-Zhe Cui, Xiao-Yong Man
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Melanocytes, melanocyte stem cells, and melanoma stem cells [PDF]
Clinics in Dermatology, 2013 Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods.
Joseph B. Mascarenhas +2 more
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Melanocyte Mitogens Induce Both Melanocyte Chemokinesis and Chemotaxis
Journal of Investigative Dermatology, 1995 It is believed that during repigmentation of vitiligo, inactive melanocytes in the outer root sheath of the hair follicle become activated, proliferate, and migrate into the depigmented skin. However, the mechanisms controlling melanocyte migration remain to be elucidated.
Jeffrey B. Travers +5 more
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Cytogenetics of Melanocytic Tumors
Journal of Investigative Dermatology, 1993 Chromosome studies of human melanocytic tumors have demonstrated non-random karyotypic abnormalities of chromosomes 1, 6, 7, 9, and 10. These visible genetic alterations may provide clues to the location of oncogenes and suppressor genes involved in the development of lesions from benign nervus to metastatic melanoma, and to the mechanisms by which the
Annette H. Parmiter, Peter C. Nowell
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Transplantation of Human Melanocytes
Journal of Investigative Dermatology, 1987 Recent advances in the culturing of pigment cells from human beings have made it possible to begin the transplantation of autologous melanocytes into areas of skin that are hypopigmented. In a patient with piebaldism we were able to take pigment cells from a shave biopsy of the normally pigmented skin of the back, expand the cells in culture, and ...
Gisela Moellmann +3 more
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