Results 1 to 10 of about 84,093 (215)

Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma [PDF]

, 2014
Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view. Diagnostic and prognostic tools are then mostly based on dermoscopic examination and morphological analysis of histological tissues.
Alemi, Alexander A., Ciusani, Emilio, La Porta, Caterina A. M., Sethna, James P., Taloni, Alessandro, Zapperi, Stefano   +5 more
arxiv   +9 more sources

Frontiers in Pigment Cell and Melanoma Research [PDF]

arXiv, 2018
We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences.
Birlea, Stanca, Bosenberg, Marcus W., Box, Neil F., Brash, Douglas, Cassidy, Pamela B., Chen, Suzie, D'Orazio, John August, Filipp, Fabian V., Fujita, Mayumi, Goh, Boon-Kee, Herlyn, Meenhard, Indra, Arup K., Larue, Lionel, Leachman, Sancy A., Liu-Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A., Poole, Caroline Le, Shellman, Yiqun, Smalley, Keiran S. M., Spritz, Richard A., Sturm, Richard A., Swetter, Susan M., Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S.   +26 more
arxiv   +3 more sources

Hair follicle-derived melanocyte transplant as a promising treatment strategy for vitiligo [PDF]

Stem Cell Research & Therapy
Background The global incidence of vitiligo has been increasing in recent years, imposing psychological distress and social pressure owing to its refractory and recurrent nature.
Ruirui Fan, Jie Gao, Jin Chen
doaj   +2 more sources

Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells [PDF]

Frontiers in Physiology
IntroductionRecent findings show that visible light, particularly blue light, stimulates melanogenesis in human skin, though the underlying mechanisms remain debated.
Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Brice Magne, Brice Magne, Brice Magne, Karel Ferland, Karel Ferland, Karel Ferland, Natallia E. Uzunbajakava, Daniel Barolet, Daniel Barolet, Lucie Germain, Lucie Germain, Lucie Germain   +15 more
doaj   +2 more sources

BRN2 is a non-canonical melanoma tumor-suppressor

Nature Communications, 2021
The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the ...
Michael Hamm, Pierre Sohier, Valérie Petit, Jérémy H. Raymond, Véronique Delmas, Madeleine Le Coz, Franck Gesbert, Colin Kenny, Zackie Aktary, Marie Pouteaux, Florian Rambow, Alain Sarasin, Nisamanee Charoenchon, Alfonso Bellacosa, Luis Sanchez-del-Campo, Laura Mosteo, Martin Lauss, Dies Meijer, Eirikur Steingrimsson, Göran B. Jönsson, Robert A. Cornell, Irwin Davidson, Colin R. Goding, Lionel Larue   +23 more
doaj   +1 more source

ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity

Molecular Cancer, 2021
Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies.
Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto, Robert Ballotti   +14 more
doaj   +1 more source

Cutaneous and uveal melanoma: two different cancers in therapeutic needs

Comptes Rendus Biologies, 2021
Melanocytes are located in various parts of the human body, such as the skin and the eye. Their transformation leads to melanoma, an aggressive and deadly neoplasm.
Bertolotto, Corine
doaj   +1 more source

Correction to: ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity

Molecular Cancer, 2021
An amendment to this paper has been published and can be accessed via the original article.
Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto, Robert Ballotti   +14 more
doaj   +1 more source

A role for Dynlt3 in melanosome movement, distribution, acidity and transfer

Communications Biology, 2021
Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the ...
Zackie Aktary, Alejandro Conde-Perez, Florian Rambow, Mathilde Di Marco, François Amblard, Ilse Hurbain, Graça Raposo, Cédric Delevoye, Sylvie Coscoy, Lionel Larue   +9 more
doaj   +1 more source

Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis

Cells, 2022
Melanocytes produce melanin to protect the skin from UV-B radiation. Notwithstanding, the spectrum of their functions extends far beyond their well-known role as melanin production factories.
Yan-Yan Chen, Li-Ping Liu, Hang Zhou, Yun-Wen Zheng, Yu-Mei Li   +4 more
doaj   +1 more source