Results 1 to 10 of about 123,035 (391)
Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance This study expands understanding of opsin 3 (OPN3) function and of skin pigmentation. The findings presented here reveal that the nonvisual OPN3 modulates the pigmentation of human epidermal melanocytes—the melanin-producing cells of the ...
Lauren E Olinski +2 more
exaly +3 more sources
The genomic landscapes of individual melanocytes from human skin
Nature, 2020 Every cell in the human body has a unique set of somatic mutations, but it remains difficult to comprehensively genotype an individual cell 1 . Here we describe ways to overcome this obstacle in the context of normal human skin, thus offering a glimpse ...
Eleanor Fewings +2 more
exaly +2 more sources
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction
EMBO Journal, 2019 Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that melanocytes are the only epidermal cell type to express the senescence marker p16INK4A during human skin ...
Stella Victorelli +2 more
exaly +2 more sources
Scientific Reports, 2017 Ultraviolet light (UV) is an inducer of reactive oxygen species (ROS) as well as 6-4-photoproducts and cyclobutane pyrimidine dimers (CPD) in the skin, which further cause damage to the skin cells.
Zorica Janjetovic +2 more
exaly +2 more sources
Melanocytes as Instigators and Victims of Oxidative Stress
Journal of Investigative Dermatology, 2014 Epidermal melanocytes are particularly vulnerable to oxidative stress due to the pro-oxidant state generated during melanin synthesis, and to intrinsic antioxidant defences that are compromised in pathologic conditions.
Sancy A Leachman, Zalfa A Abdel-Malek
exaly +2 more sources
Hair follicle-derived melanocyte transplant as a promising treatment strategy for vitiligo [PDF]
Stem Cell Research & TherapyBackground The global incidence of vitiligo has been increasing in recent years, imposing psychological distress and social pressure owing to its refractory and recurrent nature.
Ruirui Fan, Jie Gao, Jin Chen
doaj +2 more sources
Bioprinting of biomimetic skin containing melanocytes
Experimental Dermatology, 2018 Wonhye Lee, Il-Hong Bae, Seung-Schik Yoo
exaly +2 more sources
From neural crest cells to melanocytes: cellular plasticity during development and beyond
Cellular and Molecular Life Sciences, 2019 Geert Berx
exaly +2 more sources
MITF in Normal Melanocytes, Cutaneous and Uveal Melanoma: A Delicate Balance
International Journal of Molecular Sciences, 2022 Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. Although it has been studied extensively in cutaneous melanoma, the role of MITF in uveal melanoma (UM) has not been explored in ...
M. Gelmi +4 more
semanticscholar +1 more source