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BRN2 is a non-canonical melanoma tumor-suppressor
Nature Communications, 2021 The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the ...
Michael Hamm +23 more
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Molecular Cancer, 2021 Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies.
Yann Cheli +14 more
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Molecular Cancer, 2021 An amendment to this paper has been published and can be accessed via the original article.
Yann Cheli +14 more
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Cutaneous and uveal melanoma: two different cancers in therapeutic needs
Comptes Rendus Biologies, 2021 Melanocytes are located in various parts of the human body, such as the skin and the eye. Their transformation leads to melanoma, an aggressive and deadly neoplasm.
Bertolotto, Corine
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A role for Dynlt3 in melanosome movement, distribution, acidity and transfer
Communications Biology, 2021 Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the ...
Zackie Aktary +9 more
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Cells, 2022 Melanocytes produce melanin to protect the skin from UV-B radiation. Notwithstanding, the spectrum of their functions extends far beyond their well-known role as melanin production factories.
Yan-Yan Chen +4 more
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Successful Repigmentation of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei)
Animals, 2022 Fraser’s dolphins (Lagenodelphis hosei) exhibit the capability to restore nearly normal pigmentation after full-thickness wounding. However, the association among melanocytes, melanin and skin pigmentation during wound healing in cetaceans has yet to be ...
Chen-Yi Su +5 more
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Stem Cell Research & Therapy, 2023 Background Melanocytes are an essential part of the epidermis, and their regeneration has received much attention because propagation of human adult melanocytes in vitro is too slow for clinical use.
Chie Kobori +10 more
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Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes
Current Issues in Molecular Biology, 2021 Skin melanocytes harbor a complex photosensitive system comprised of opsins, which were shown, in recent years, to display light- and thermo-independent functions.
Leonardo Vinícius Monteiro de Assis +5 more
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Melanoma Risk and Melanocyte Biology
Acta Dermato-Venereologica, 2020 Cutaneous melanoma arises from melanocytes following genetic, epigenetic and allogenetic (i.e. other than epi/genetic) modifications. An estimated 10% of cutaneous melanoma cases are due to inherited variants or de novo mutations in approximately 20 ...
Julie U. Bertrand +4 more
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