A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma. [PDF]
, 2011 MicroRNAs (miRNAs) are small ∼22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3' untranslated region (3' UTRs) of target gene messenger RNAs (mRNA).
Ariyan, S +16 more
core +1 more source
Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets
Food Safety and Health, EarlyView.Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar +5 more
wiley +1 more source
Biochemistry and Biophysics Reports, 2019 Mouse melanoma B16-BL6 cells are useful cells for cancer metastatic studies. To understand the metastatic principle at molecular levels, it is necessary to carry out experiments in which cancer cells and their normal counterparts are compared.
Nahoko Tomonobu +8 more
doaj
Spatial cancer systems biology resolves heterotypic interactions and identifies disruption of spatial hierarchy as a pathological driver event [PDF]
arXiv, 2023 Spatially annotated single-cell datasets provide unprecedented opportunities to dissect cell-cell communication in development and disease. Heterotypic signaling includes interactions between different cell types and is well established in tissue development and spatial organization.
arxiv
MicroRNAs in melanoma development and resistance to target therapy [PDF]
, 2017 microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio +7 more
core +1 more source
SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity
International Journal of Cancer, EarlyView.Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai +6 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? Adoptive cell therapy (ACT) with tumor antigen‐specific CD8+ T cells has shown success in clinical trials treating patients with advanced or metastatic melanoma. Here, the authors established protocols for generating CD8+ T cells from human induced pluripotent stem cells (hiPSCs) expressing a melanoma‐specific T cell receptor (TCR) or ...
Juliane Poelchen +13 more
wiley +1 more source
Worldwide Cutaneous Malignant Melanoma Incidences Analyzed by Sex, Age, and Skin Type Over Time (1955–2007): Is HPV Infection of Androgenic Hair Follicular Melanocytes a Risk Factor for Developing Melanoma Exclusively in People of European-Ancestry? [PDF]
, 2016 The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades.
Merrill, Stephen +2 more
core +3 more sources
A Case of Primary Urethral Malignant Melanoma With Persistent Bleeding and Severe Anemia
IJU Case Reports, EarlyView.ABSTRACT Introduction Primary malignant melanomas of the urethra are extremely rare. The initial symptoms typically include hematuria or genital bleeding. This report describes a case of a massive primary urethral malignant melanoma with persistent bleeding.
Tatsuma Juichi +6 more
wiley +1 more source
Segmentation of Cellular Patterns in Confocal Images of Melanocytic Lesions in vivo via a Multiscale Encoder-Decoder Network (MED-Net) [PDF]
arXiv, 2020 In-vivo optical microscopy is advancing into routine clinical practice for non-invasively guiding diagnosis and treatment of cancer and other diseases, and thus beginning to reduce the need for traditional biopsy. However, reading and analysis of the optical microscopic images are generally still qualitative, relying mainly on visual examination.
arxiv