Results 141 to 150 of about 85,786 (342)

High charge of cerebroid nests in nodular melanomas predicts tumor aggressiveness and high mutational tumoral burden: a pilot study

Frontiers in Oncology
PurposeEven today, melanoma is a highly aggressive neoplasm with a high mortality rate. The nodular type is very aggressive and has cerebroid nests of melanocytes (CNMs) at the growth edge, morphologically similar to the poorly differentiated neoplastic ...
Stefania Caramaschi, Stefania Caramaschi, Alessandro Mangogna, Laura Bertoni, Marco Manfredini, Francesca Farnetani, Paola Parente, Vito Attino, Gerardo Cazzato, Tiziana Salviato, Giovanni Pellacani, Luca Reggiani Bonetti, Luca Reggiani Bonetti   +12 more
doaj   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

The Difference Between Polymyxin B and Polymyxin E in Causing Skin Hyerpigmentation

Frontiers in Pharmacology, 2021
Dongna Zou, Haitao Yu, Feifei Li
doaj   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection

Frontiers in Medicine
IntroductionDaily solar ultraviolet (UV) radiation has an important impact on skin health. Understanding the initial events of the UV-induced response is critical to prevent deleterious conditions.
Paola De Los Santos Gomez, Lydia Costello, Kirsty Goncalves, Stefan Przyborski, Stefan Przyborski   +4 more
doaj   +1 more source

An Enlarging Mass Superimposed on a Giant Congenital Melanocytic Nevus: A Case Report and Review of Literature. [PDF]

Clin Case Rep
ABSTRACT Congenital melanocytic nevi (CMN), arising from the proliferation of melanocytes, manifest at birth and are colloquially termed as bathing trunk, coat‐sleeve, or stocking nevi. These lesions, occurring in approximately 1 to 2% of neonates, predominantly localize over the trunk and thigh regions.
Al-Zubaidi N, Sayna S, Kani ZA, Gheisari M, Zahedi K.   +4 more
europepmc   +2 more sources

Identification of α- and β-Melanocyte-Stimulating Hormone in Hog Posterior Pituitary Powder

, 1958
Teh H. Lee
openalex   +1 more source

Look past the cooperative eye hypothesis: reconsidering the evolution of human eye appearance

Biological Reviews, EarlyView.
ABSTRACT The external appearance of the human eye has been prominently linked to the evolution of complex sociocognitive functions in our species. The cooperative eye hypothesis (CEH) proposes that human eyeballs, with their weakly expressed conjunctival and scleral pigmentation, are uniquely conspicuous and evolved under selective pressures to behave ...
Juan Olvido Perea‐García, Aurora Teuben, Kai R. Caspar   +2 more
wiley   +1 more source

Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells

Frontiers in Physiology
IntroductionRecent findings show that visible light, particularly blue light, stimulates melanogenesis in human skin, though the underlying mechanisms remain debated.
Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Brice Magne, Brice Magne, Brice Magne, Karel Ferland, Karel Ferland, Karel Ferland, Natallia E. Uzunbajakava, Daniel Barolet, Daniel Barolet, Lucie Germain, Lucie Germain, Lucie Germain   +15 more
doaj   +1 more source

The Melanosome: A Distinctive Subcellular Particle of Mammalian Melanocytes and the Site of Melanogenesis1

, 1961
Makoto Seiji, Thomas B. Fitzpatrick, M. S. C. Birbeck   +2 more
openalex   +1 more source