Results 11 to 20 of about 85,786 (342)
Melanocytes and Their Diseases [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Human melanocytes are distributed not only in the epidermis and in hair follicles but also in mucosa, cochlea (ear), iris (eye), and mesencephalon (brain) among other tissues. Melanocytes, which are derived from the neural crest, are unique in that they produce eu-/pheo-melanin pigments in unique membrane-bound organelles termed melanosomes, which can ...
Vincent J. Hearing, Yuji Yamaguchi
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Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma [PDF]
, 2014 Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view.
Alemi, Alexander A. +5 more
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Cancer, 1988 The clinical, histopathologic, immunohistochemical, and electron microscopic findings of two cases of melanocytic schwannoma are reported. One case, which occurred in the parotid gland, is believed to be the first reported in this location. The other case was located in the sacral spinal region.
Roberta M. Killeen +2 more
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Amphiregulin Regulates Melanocytic Senescence
Cells, 2021 Oncogene-induced senescence (OIS) is a decisive process to suppress tumor development, but the molecular details of OIS are still under investigation.
Michaela Pommer +2 more
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In vitro dedifferentiation of melanocytes from adult epidermis. [PDF]
PLoS ONE, 2011 In previous work we described a novel culture technique using a cholera toxin and PMA-free medium (Mel-mix) for obtaining pure melanocyte cultures from human adult epidermis.
Bernadett Kormos +7 more
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Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship
Frontiers in Oncology, 2022 Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet radiation and other environmental stressors. It is produced by the enzymatic transformation of L-tyrosine to dopaquinone and subsequent chemical and ...
Radomir M. Slominski +6 more
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Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]
, 2013 Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
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Development of the stria vascularis and potassium regulation in the human fetal cochlea : insights into hereditary sensorineural hearing loss [PDF]
, 2015 Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression
Chuva de Sousa Lopes, Susana Marina +5 more
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Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway [PDF]
, 2009 Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Abdel-Malek +45 more
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Cell Reports, 2015 Molecular signatures specific to particular tumor types are required to design treatments for resistant tumors. However, it remains unclear whether tumors and corresponding cell lines used for drug development share such signatures.
Florian Rambow +13 more
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