Coordinated regulation of chromatophore differentiation and melanogenesis during the ontogeny of skin pigmentation of Solea senegalensis (Kaup, 1858) [PDF]
, 2013 Abnormal pigmentation of Senegalese sole has been described as one problem facing the full exploitation of its commercial production. To improve our understanding of flatfish pigmentation of this commercially important species we have evaluated eleven ...
Alicia Estévez +6 more
core +15 more sources
Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes
Current Issues in Molecular Biology, 2021 Skin melanocytes harbor a complex photosensitive system comprised of opsins, which were shown, in recent years, to display light- and thermo-independent functions.
Leonardo Vinícius Monteiro de Assis +5 more
doaj +1 more source
Melanoma Risk and Melanocyte Biology
Acta Dermato-Venereologica, 2020 Cutaneous melanoma arises from melanocytes following genetic, epigenetic and allogenetic (i.e. other than epi/genetic) modifications. An estimated 10% of cutaneous melanoma cases are due to inherited variants or de novo mutations in approximately 20 ...
Julie U. Bertrand +4 more
doaj +1 more source
Amphiregulin Regulates Melanocytic Senescence
Cells, 2021 Oncogene-induced senescence (OIS) is a decisive process to suppress tumor development, but the molecular details of OIS are still under investigation.
Michaela Pommer +2 more
doaj +1 more source
Human cutaneous interfollicular melanocytes differentiate temporarily under genotoxic stress
iScience, 2022 Summary: DNA-damage response of cutaneous interfollicular melanocytes to fractionated radiotherapy was investigated by immunostaining of tissue sections from punch biopsies collected before, during, and after the treatment of patients for breast cancer ...
Per Fessé +5 more
doaj +1 more source
In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]
, 2015 Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B. +12 more
core +2 more sources
In vitro dedifferentiation of melanocytes from adult epidermis. [PDF]
PLoS ONE, 2011 In previous work we described a novel culture technique using a cholera toxin and PMA-free medium (Mel-mix) for obtaining pure melanocyte cultures from human adult epidermis.
Bernadett Kormos +7 more
doaj +1 more source
Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway [PDF]
, 2009 Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Abdel-Malek +45 more
core +2 more sources
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]
, 2016 The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H. +5 more
core +1 more source
The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions [PDF]
, 2011 C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit
Atzori L +9 more
core +1 more source