Results 21 to 30 of about 85,786 (342)
Imiquimod induced vitiligo‐like lesions—A consequence of modified melanocyte function
Immunity, Inflammation and Disease, 2022 Introduction Imiquimod plays an important role in the management of condyloma and premalignant lesions. Successively, an increase of hypopigmented lesions following imiquimod application has been reported.
Haiyan Yu +4 more
doaj +1 more source
In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]
, 2015 Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B. +12 more
core +2 more sources
The biology of melanocyte and melanocyte stem cell [PDF]
Acta Biochimica et Biophysica Sinica, 2014 The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations.
openaire +3 more sources
Deubiquitination of MITF-M Regulates Melanocytes Proliferation and Apoptosis
Frontiers in Molecular Biosciences, 2021 Microphthalmia-associated transcription factor-M (MITF-M) is the key gene in the proliferation and differentiation of melanocytes, which undergoes an array of post-translation modifications.
Shuaishuai Hu +12 more
doaj +1 more source
DHODH modulates transcriptional elongation in the neural crest and melanoma [PDF]
, 2011 Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the ...
AD Boiko +46 more
core +1 more source
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
Frontiers in Cardiovascular Medicine, 2021 Objective: Aortic valve (AV) leaflets rely on a precise extracellular matrix (ECM) microarchitecture for appropriate biomechanical performance. The ECM structure is maintained by valvular interstitial cells (VICs), which reside within the leaflets.
Joshua D. Hutcheson +18 more
doaj +1 more source
Vitiligo and autoimmune thyroid disorders [PDF]
, 2017 Vitiligo represents the most common cause of acquired skin, hair and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte ...
Baldini, Enke +10 more
core +2 more sources
Is there a correlation between vitiligo and hearing loss? - review of the literature
Journal of Education, Health and Sport, 2022 Vitiligo is the most common cause of hipopigmentation occuring with a frequency of 0.5-2% relying on impairment of melanin production caused by the loss of melanocytes.
Barbara Rusinowska
doaj +1 more source
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1. [PDF]
, 2018 Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development.
Carlson, Daniel F +21 more
core +2 more sources
Melanocytic Nevus of the Colon [PDF]
Case Reports in Gastroenterology, 2019 Here, we report a very rare case of melanocytic nevus of the colon. A 54-year-old woman with an unremarkable medical history visited our hospital for screening colonoscopy. Colonoscopy revealed a pigmented flat lesion in the ascending colon. Histological evaluation of a biopsy specimen revealed proliferation of pigmented cells in the lamina muscularis ...
Tamotsu Sugai +5 more
openaire +3 more sources