Results 21 to 30 of about 123,035 (391)

Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes

Current Issues in Molecular Biology, 2021
Skin melanocytes harbor a complex photosensitive system comprised of opsins, which were shown, in recent years, to display light- and thermo-independent functions.
Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes, Davi Mendes, Matheus Molina Silva, Carlos Frederico Martins Menck, Ana Maria de Lauro Castrucci   +5 more
doaj   +1 more source

“Transcription physiology” of pigment formation in melanocytes: central role of MITF

Experimental Dermatology, 2010
Jiri Vachtenheim
exaly   +2 more sources

Amphiregulin Regulates Melanocytic Senescence

Cells, 2021
Oncogene-induced senescence (OIS) is a decisive process to suppress tumor development, but the molecular details of OIS are still under investigation.
Michaela Pommer, Silke Kuphal, Anja K. Bosserhoff   +2 more
doaj   +1 more source

Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO‐1 pathway

Journal of Cellular and Molecular Medicine, 2020
As a main part of pigmentation disorders, skin depigmentation diseases such as vitiligo and achromic naevus are very common and get more attention now. The pathogenesis of depigmentation includes melanocyte dysfunction and loss, which are possibly caused
Yibo Hu, Jinhua Huang, Yixiao Li, Ling Jiang, Yujie Ouyang, Yumeng Li, Lun Yang, Xiaojiao Zhao, Lihua Huang, Hong Xiang, J. Chen, Q. Zeng   +11 more
semanticscholar   +1 more source

Melanoma Risk and Melanocyte Biology

Acta Dermato-Venereologica, 2020
Cutaneous melanoma arises from melanocytes following genetic, epigenetic and allogenetic (i.e. other than epi/genetic) modifications. An estimated 10% of cutaneous melanoma cases are due to inherited variants or de novo mutations in approximately 20 ...
Julie U. Bertrand, Eirikur Steingrimsson, Fanélie Jouenne, Brigitte Bressac-de Paillerets, Lionel Larue   +4 more
doaj   +1 more source

Human cutaneous interfollicular melanocytes differentiate temporarily under genotoxic stress

iScience, 2022
Summary: DNA-damage response of cutaneous interfollicular melanocytes to fractionated radiotherapy was investigated by immunostaining of tissue sections from punch biopsies collected before, during, and after the treatment of patients for breast cancer ...
Per Fessé, Jan Nyman, Ingegerd Hermansson, Maj-Lis Book, Johan Ahlgren, Ingela Turesson   +5 more
doaj   +1 more source

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +2 more sources

Dysfunction of ATG7-dependent autophagy dysregulates the antioxidant response and contributes to oxidative stress-induced biological impairments in human epidermal melanocytes

Cell Death Discovery, 2020
Autophagy is a process involving the self-digestion of components that participates in anti-oxidative stress responses and protects cells against oxidative damage.
Zhuhui Qiao, Zhongyi Xu, Qing Xiao, Yiwen Yang, Jiayi Ying, L. Xiang, Chengfeng Zhang   +6 more
semanticscholar   +1 more source

In vitro dedifferentiation of melanocytes from adult epidermis. [PDF]

PLoS ONE, 2011
In previous work we described a novel culture technique using a cholera toxin and PMA-free medium (Mel-mix) for obtaining pure melanocyte cultures from human adult epidermis.
Bernadett Kormos, Nóra Belso, Attila Bebes, Gábor Szabad, Sarolta Bacsa, Márta Széll, Lajos Kemény, Zsuzsanna Bata-Csörgo   +7 more
doaj   +1 more source

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source