Cell Reports, 2015 Molecular signatures specific to particular tumor types are required to design treatments for resistant tumors. However, it remains unclear whether tumors and corresponding cell lines used for drug development share such signatures.
Florian Rambow +13 more
doaj +1 more source
The biology of melanocyte and melanocyte stem cell [PDF]
Acta Biochimica et Biophysica Sinica, 2014 The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations.
openaire +3 more sources
Vitiligo and autoimmune thyroid disorders [PDF]
, 2017 Vitiligo represents the most common cause of acquired skin, hair and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte ...
Baldini, Enke +10 more
core +2 more sources
Mechanisms contributing to differential regulation of PAX3 downstream target genes in normal human epidermal melanocytes versus melanoma cells. [PDF]
PLoS ONE, 2015 Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of these melanocytes is driven by the transcription factor PAX3 early during embryonic development.
Danielle Bartlett +3 more
doaj +1 more source
Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]
, 2013 Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
core +1 more source
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
Frontiers in Cardiovascular Medicine, 2021 Objective: Aortic valve (AV) leaflets rely on a precise extracellular matrix (ECM) microarchitecture for appropriate biomechanical performance. The ECM structure is maintained by valvular interstitial cells (VICs), which reside within the leaflets.
Joshua D. Hutcheson +18 more
doaj +1 more source
Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]
, 2014 Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Aguilar-Guzmán, L +11 more
core +2 more sources
Deubiquitination of MITF-M Regulates Melanocytes Proliferation and Apoptosis
Frontiers in Molecular Biosciences, 2021 Microphthalmia-associated transcription factor-M (MITF-M) is the key gene in the proliferation and differentiation of melanocytes, which undergoes an array of post-translation modifications.
Shuaishuai Hu +12 more
doaj +1 more source
Worldwide Cutaneous Malignant Melanoma Incidences Analyzed by Sex, Age, and Skin Type Over Time (1955–2007): Is HPV Infection of Androgenic Hair Follicular Melanocytes a Risk Factor for Developing Melanoma Exclusively in People of European-Ancestry? [PDF]
, 2016 The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades.
Godar, Dianne E. +2 more
core +3 more sources
Biochemistry and Biophysics Reports, 2019 Mouse melanoma B16-BL6 cells are useful cells for cancer metastatic studies. To understand the metastatic principle at molecular levels, it is necessary to carry out experiments in which cancer cells and their normal counterparts are compared.
Nahoko Tomonobu +8 more
doaj +1 more source