Results 21 to 30 of about 116,555 (410)

Amphiregulin Regulates Melanocytic Senescence

Cells, 2021
Oncogene-induced senescence (OIS) is a decisive process to suppress tumor development, but the molecular details of OIS are still under investigation.
Michaela Pommer, Silke Kuphal, Anja K. Bosserhoff   +2 more
doaj   +1 more source

Dysfunction of ATG7-dependent autophagy dysregulates the antioxidant response and contributes to oxidative stress-induced biological impairments in human epidermal melanocytes

Cell Death Discovery, 2020
Autophagy is a process involving the self-digestion of components that participates in anti-oxidative stress responses and protects cells against oxidative damage.
Zhuhui Qiao, Zhongyi Xu, Qing Xiao, Yiwen Yang, Jiayi Ying, L. Xiang, Chengfeng Zhang   +6 more
semanticscholar   +1 more source

In vitro dedifferentiation of melanocytes from adult epidermis. [PDF]

PLoS ONE, 2011
In previous work we described a novel culture technique using a cholera toxin and PMA-free medium (Mel-mix) for obtaining pure melanocyte cultures from human adult epidermis.
Bernadett Kormos, Nóra Belso, Attila Bebes, Gábor Szabad, Sarolta Bacsa, Márta Széll, Lajos Kemény, Zsuzsanna Bata-Csörgo   +7 more
doaj   +1 more source

Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]

, 2013
Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
core   +1 more source

Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship

Frontiers in Oncology, 2022
Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet radiation and other environmental stressors. It is produced by the enzymatic transformation of L-tyrosine to dopaquinone and subsequent chemical and ...
Radomir M. Slominski, Tadeusz Sarna, Przemysław M. Płonka, Chander Raman, Anna A. Brożyna, Andrzej T. Slominski, Andrzej T. Slominski   +6 more
doaj   +1 more source

Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling. [PDF]

, 2014
Long-wave UVA is the major component of terrestrial UV radiation and is also the predominant constituent of indoor sunlamps, both of which have been shown to increase cutaneous melanoma risk.
Rajadurai, A, Redmond, RW, Sviderskaya, EV, Tsao, H, Udayakumar, D   +4 more
core   +2 more sources

Development of the stria vascularis and potassium regulation in the human fetal cochlea : insights into hereditary sensorineural hearing loss [PDF]

, 2015
Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression
Chuva de Sousa Lopes, Susana Marina, de Groot, John CMJ, Frijns, Johan HM, Huisman, Margriet A, Locher, Heiko, van Iperen, Liesbeth   +5 more
core   +2 more sources

Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism [PDF]

, 2012
Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation.
Abraham, Ackermann, Ang Li, Balch, Balch, Bauer, Buccione, Cook, Demunter, Downward, Edward, Fuchs, Furmaniak-Kazmierczak, Gray-Schopfer, Hancock, Hendrix, Hirobe, Jaffe, Karen Blyth, Karreth, Kelsh, Kissil, Kunisada, Larue, Laura M. Machesky, Li, Li, Linder, Lionel Larue, Luciani, Mackenzie, Malumbres, Marshall, McCalmont, Meng Jin, Mishra, Mort, Nakahara, Owen J. Sansom, Peters, Platz, Qiu, Richard L. Mort, Sahai, Samuel, Scott, Sharov, Susan Mason, Vidali, Whitwam, Yafeng Ma, Yamaguchi, Yang   +52 more
core   +1 more source

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

EMBO Journal, 2019
Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that melanocytes are the only epidermal cell type to express the senescence marker p16INK4A during human skin ...
Stella G. Victorelli, A. Lagnado, Jessica Halim, Willam Moore, D. Talbot, Karen Barrett, James Chapman, J. Birch, M. Ogrodnik, A. Meves, Jeff S Pawlikowski, D. Jurk, Peter D. Adams, D. Heemst, M. Beekman, P. Slagboom, David A. Gunn, João F. Passos   +17 more
semanticscholar   +1 more source

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis

Cell Reports, 2015
Molecular signatures specific to particular tumor types are required to design treatments for resistant tumors. However, it remains unclear whether tumors and corresponding cell lines used for drug development share such signatures.
Florian Rambow, Bastien Job, Valérie Petit, Franck Gesbert, Véronique Delmas, Hannah Seberg, Guillaume Meurice, Eric Van Otterloo, Philippe Dessen, Caroline Robert, Daniel Gautheret, Robert A. Cornell, Alain Sarasin, Lionel Larue   +13 more
doaj   +1 more source