Results 41 to 50 of about 48,156 (309)

Current Concepts of Vitiligo Immunopathogenesis

Biomedicines, 2022
Vitiligo is an acquired immune-mediated disorder of pigmentation clinically characterized by well-defined depigmented or chalk-white macules and patches on the skin.
Nika Hlača, Tina Žagar, Marija Kaštelan, Ines Brajac, Larisa Prpić-Massari   +4 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents

Pharmaceuticals, 2023
Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ...
Sandra Mota, Gonçalo P. Rosa, Maria Carmo Barreto, Jorge Garrido, Emília Sousa, Maria T. Cruz, Isabel F. Almeida, Clara Quintas   +7 more
doaj   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

A modelling approach towards Epidermal homoeostasis control

, 2007
In order to grasp the features arising from cellular discreteness and individuality, in large parts of cell tissue modelling agent-based models are favoured.
Barthel, Bashir, Bauer, Benoit, Bettelheim, Brilliantov, Byrne, Carvalho, Chenevert, Chu, Cickovski, Dallon, Dormann, Drasdo, Drasdo, Edelsbrunner, Ferreira, Fletcher, Freyer, Freyer, Galle, Galle, Gardner, Gatenby, Gernot Schaller, Gershenfeld, Graner, Hertz, Hoath, Johnson, Johnson, Joos, Kasting, Kreft, Kreft, Kreft, Landau, Livingston, Louzoun, Mahaffy, Maniotis, Meineke, Meyer-Hermann, Michael Meyer-Hermann, Montagna, Moy, Newman, Norlen, Picioreanu, Potten, Press, Savill, Schaller, Schaller, Schaller, Schwindt, Smolle, Tang, Tuchin, Turner, Verdier, von Neumann, Wehrle, Weliky, Weliky   +64 more
core   +1 more source

MicroRNA-206 Regulation of Skin Pigmentation in Koi Carp (Cyprinus carpio L.)

Frontiers in Genetics, 2020
MicroRNAs (miRNAs) are ∼22 nucleotide non-coding RNA molecules that act as crucial roles in plenty of biological processes. However, the molecular and cellular mechanisms of miRNAs to regulate skin color differentiation and pigmentation in fish have not ...
Zaijie Dong, Zaijie Dong, Mingkun Luo, Lanmei Wang, Haoran Yin, Wenbin Zhu, Jianjun Fu   +6 more
doaj   +1 more source

Melanocytes, melanocyte stem cells, and melanoma stem cells [PDF]

Clinics in Dermatology, 2013
Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods.
Joseph B. Mascarenhas, Christopher R. Shea, Deborah Lang   +2 more
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Biology of melanocytes in mammals

Frontiers in Cell and Developmental Biology, 2023
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessing a dendritic morphology. These cells migrate to the epidermis and follicles, contributing to skin and hair pigmentation during embryonic development.
Ying-Zhe Cui, Xiao-Yong Man
openaire   +3 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source