Results 41 to 50 of about 116,555 (410)

Graded potential of neural crest to form cornea, sensory neurons and cartilage along the rostrocaudal axis [PDF]

, 2004
Neural crest cells arising from different rostrocaudal axial levels form different sets of derivatives as diverse as ganglia, cartilage and cornea. These variations may be due to intrinsic properties of the cell populations, different environmental ...
Bronner-Fraser, Marianne, Conrad, Gary W., Lwigale, Peter Y.   +2 more
core   +2 more sources

HGF/c-MET Signaling in Melanocytes and Melanoma

International Journal of Molecular Sciences, 2018
Hepatocyte growth factor (HGF)/ mesenchymal-epithelial transition factor (c-MET) signaling is involved in complex cellular programs that are important for embryonic development and tissue regeneration, but its activity is also utilized by cancer cells ...
M. Czyż
semanticscholar   +1 more source

Learning Melanocytic Cell Masks from Adjacent Stained Tissue [PDF]

arXiv, 2022
Melanoma is one of the most aggressive forms of skin cancer, causing a large proportion of skin cancer deaths. However, melanoma diagnoses by pathologists shows low interrater reliability. As melanoma is a cancer of the melanocyte, there is a clear need to develop a melanocytic cell segmentation tool that is agnostic to pathologist variability and ...
arxiv  

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways

Scientific Reports, 2017
Ultraviolet light (UV) is an inducer of reactive oxygen species (ROS) as well as 6-4-photoproducts and cyclobutane pyrimidine dimers (CPD) in the skin, which further cause damage to the skin cells.
Z. Janjetović, S. Jarrett, Elizabeth Lee, Cory Duprey, R. Reiter, A. Slominski   +5 more
semanticscholar   +1 more source

Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling [PDF]

, 2015
Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61.
Adams, P.D., Al-Olabi, L., Blyth, K., Brock, C., Chanudet, E., Chen, S.-C., Holmes, W.M., King, A., Kinsler, V.A., Lambie, W., McGregor, F., Mullin, J.M., Nixon, C., Paine, S., Pawlikowski, J.S., Richmond, A., Wu, H.   +16 more
core   +2 more sources

Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes*

Journal of Biological Chemistry, 2016
Olfactory receptors, which belong to the family of G-protein-coupled receptors, are found to be ectopically expressed in non-sensory tissues mediating a variety of cellular functions.
L. Gelis, Nikolina Jovancevic, Sophie Veitinger, Bhubaneswar Mandal, Hans‐Dieter Arndt, E. Neuhaus, H. Hatt   +6 more
semanticscholar   +1 more source

Deubiquitination of MITF-M Regulates Melanocytes Proliferation and Apoptosis

Frontiers in Molecular Biosciences, 2021
Microphthalmia-associated transcription factor-M (MITF-M) is the key gene in the proliferation and differentiation of melanocytes, which undergoes an array of post-translation modifications.
Shuaishuai Hu, Shaocheng Bai, Yingying Dai, Naisu Yang, Jiali Li, Xiyu Zhang, Fan Wang, Bohao Zhao, Guolian Bao, Yang Chen, Yang Chen, Xinsheng Wu, Xinsheng Wu   +12 more
doaj   +1 more source

DHODH modulates transcriptional elongation in the neural crest and melanoma [PDF]

, 2011
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the ...
AD Boiko, AL Rubinstein, AV Molofsky, BR Keegan, Charles Kaufman, Charles Y. Lin, Christopher J. Burke, CT Nguyen, D Mueller, Donna Neuberg, Erin Langdon, Frank Chen, GN Wheeler, Grant N. Wheeler, H Davies, Hannah K. Long, J Tsai, Jack Mosher, JE McLean, Jennifer Cech, K Krishnan, KT Flaherty, Leonard I. Zon, LM Graves, M Löffler, Martin Kramer, Matthew L. Tomlinson, MH Schiff, MJ Kaplan, PB Rahl, Peter B. Rahl, R Luo, Richard A. Young, Richard Mark White, RM Bakos, S Bixby, S Guo, SB Ng, Scott Granter, Sean Morrison, SK Hong, Sumon Datta, Sutheera Ratanasirintrawoot, T Aoki, T Wada, X Bai, Y Chen   +46 more
core   +1 more source

Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes

bioRxiv, 2017
Most expression quantitative trait loci (eQTL) studies to date have been performed in heterogenous tissues as opposed to specific cell types. To better understand the cell-type specific regulatory landscape of human melanocytes, which give rise to ...
Tongwu Zhang, Jiyeon Choi, Michael A. Kovacs, Jianxin Shi, Mai Xu, A. Goldstein, M. Iles, S. Macgregor, L. Amundadottir, M. Law, S. Loftus, W. Pavan, K. Brown   +12 more
semanticscholar   +1 more source