Results 51 to 60 of about 123,035 (391)

Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes

bioRxiv, 2017
Most expression quantitative trait loci (eQTL) studies to date have been performed in heterogenous tissues as opposed to specific cell types. To better understand the cell-type specific regulatory landscape of human melanocytes, which give rise to ...
Tongwu Zhang, Jiyeon Choi, Michael A. Kovacs, Jianxin Shi, Mai Xu, A. Goldstein, M. Iles, S. Macgregor, L. Amundadottir, M. Law, S. Loftus, W. Pavan, K. Brown   +12 more
semanticscholar   +1 more source

Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes*

Journal of Biological Chemistry, 2016
Olfactory receptors, which belong to the family of G-protein-coupled receptors, are found to be ectopically expressed in non-sensory tissues mediating a variety of cellular functions.
L. Gelis, Nikolina Jovancevic, Sophie Veitinger, Bhubaneswar Mandal, Hans‐Dieter Arndt, E. Neuhaus, H. Hatt   +6 more
semanticscholar   +1 more source

Nasopharyngeal Melanoma [PDF]

, 2018
Mucosal nasopharyngeal melanoma is a rare head and neck melanoma. Prognosis is poor (5-year overall survival rate of 10–30%) with high rates of metastases and local recurrence. Head and neck mucosal melanoma represents 0.8–3.7% of all melanomas and 0.03%
Calvieri, Stefano, Didona, Dario, Macrì, Giulia, Mercuri., Santo Raffaele, Paolino, Giovanni   +4 more
core   +1 more source

Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

Aspirin induces Nrf2‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress

Journal of Cellular and Molecular Medicine, 2016
The removal of hydrogen peroxide (H2O2) by antioxidants has been proven to be beneficial to patients with vitiligo. Aspirin (acetylsalicylic acid, ASA) has antioxidant activity and has great preventive and therapeutical effect in many oxidative stress ...
Z. Jian, Lingzhen Tang, X. Yi, Bangmin Liu, Qian Zhang, G. Zhu, Gang Wang, T. Gao, Chunying Li   +8 more
semanticscholar   +1 more source

A modelling approach towards Epidermal homoeostasis control

, 2007
In order to grasp the features arising from cellular discreteness and individuality, in large parts of cell tissue modelling agent-based models are favoured.
Barthel, Bashir, Bauer, Benoit, Bettelheim, Brilliantov, Byrne, Carvalho, Chenevert, Chu, Cickovski, Dallon, Dormann, Drasdo, Drasdo, Edelsbrunner, Ferreira, Fletcher, Freyer, Freyer, Galle, Galle, Gardner, Gatenby, Gernot Schaller, Gershenfeld, Graner, Hertz, Hoath, Johnson, Johnson, Joos, Kasting, Kreft, Kreft, Kreft, Landau, Livingston, Louzoun, Mahaffy, Maniotis, Meineke, Meyer-Hermann, Michael Meyer-Hermann, Montagna, Moy, Newman, Norlen, Picioreanu, Potten, Press, Savill, Schaller, Schaller, Schaller, Schwindt, Smolle, Tang, Tuchin, Turner, Verdier, von Neumann, Wehrle, Weliky, Weliky   +64 more
core   +1 more source

Anorectal Melanoma [PDF]

, 2018
Anorectal melanoma (AM) is a rare malignancy, characterized by aggressive behavior and a poor prognosis. AM is more frequent in female patients aged over 50 years.
Dario Didona, Giovanni Paolino, Giulia Macrì, Santo Raffaele Mercuri., Stefano Calvieri   +4 more
core   +1 more source

Extracellular vesicles are transferred from melanocytes to keratinocytes after UVA irradiation

Scientific Reports, 2016
Ultraviolet (UV) irradiation induces skin pigmentation, which relies on the intercellular crosstalk of melanin between melanocytes to keratinocytes.
P. Wäster, Ida Eriksson, L. Vainikka, I. Rosdahl, K. Öllinger   +4 more
semanticscholar   +1 more source

Beyond skin white spots: Vitiligo and associated comorbidities

Frontiers in Medicine, 2023
Vitiligo is a common depigmentation disorder of an unknown origin characterized by the selective loss of melanocytes, resulting in typical white macules and patches.
Zhonghui Hu, Tao Wang
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source