A Pathology Deep Learning System Capable of Triage of Melanoma Specimens Utilizing Dermatopathologist Consensus as Ground Truth [PDF]
arXiv, 2021 Although melanoma occurs more rarely than several other skin cancers, patients' long term survival rate is extremely low if the diagnosis is missed. Diagnosis is complicated by a high discordance rate among pathologists when distinguishing between melanoma and benign melanocytic lesions. A tool that allows pathology labs to sort and prioritize melanoma
arxiv
Journal of Investigative Dermatology, 1979 Choroidal melanocytes of the eyes of postnatal animals are classified as postmitotic terminally differentiated cells. They have specific granules, the melanosomes, which undergo changes qualitatively and quantitatively correlated to the animal's increasing age.
openaire +3 more sources
Melanocytes and Skin Immunity [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2015 Melanocytes in skin are melanin-producing cells that are derived from the neural crest. They migrate during embryological development and localize in the epidermis and hair follicles where they pigment skin and hair (Nishimura, 2011). Melanocytes and their production of melanin pigment (a process termed melanogenesis) have important roles in cutaneous ...
Xing-Hua Gao +3 more
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Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
Frontiers in Cardiovascular Medicine, 2021 Objective: Aortic valve (AV) leaflets rely on a precise extracellular matrix (ECM) microarchitecture for appropriate biomechanical performance. The ECM structure is maintained by valvular interstitial cells (VICs), which reside within the leaflets.
Joshua D. Hutcheson +18 more
doaj +1 more source
Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images [PDF]
arXiv, 2022 Automated region of interest detection in histopathological image analysis is a challenging and important topic with tremendous potential impact on clinical practice. The deep-learning methods used in computational pathology help us to reduce costs and increase the speed and accuracy of regions of interest detection and cancer diagnosis.
arxiv
Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography. [PDF]
, 2016 PurposeTo compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis.MethodsEnhanced-depth imaging-OCT images from 25 rhesus macaque and 30 ...
Cunefare, David +7 more
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Extracellular vesicles are transferred from melanocytes to keratinocytes after UVA irradiation
Scientific Reports, 2016 Ultraviolet (UV) irradiation induces skin pigmentation, which relies on the intercellular crosstalk of melanin between melanocytes to keratinocytes.
P. Wäster +4 more
semanticscholar +1 more source
MiR-217 inhibition relieves oxidative stress-induced melanocyte damage by targeting sirtuin 1
Biotechnology & Biotechnological Equipment, 2020 Vitiligo is caused by the disappearance of melanocyte function in the skin, but the mechanism has not been fully elucidated. This study aimed to investigate the expression and role of miR-217 in dysfunctional human primary melanocytes caused by oxidative
Bo Huang, Xuecheng Sun, Aie Xu
doaj +1 more source
Is there a correlation between vitiligo and hearing loss? - review of the literature
Journal of Education, Health and Sport, 2022 Vitiligo is the most common cause of hipopigmentation occuring with a frequency of 0.5-2% relying on impairment of melanin production caused by the loss of melanocytes.
Barbara Rusinowska
doaj +1 more source
Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease [PDF]
, 2020 A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as "guttate leukoderma," this skin finding is a rarely-reported presentation of Darier disease.
Grossman, Shoshana K +4 more
core