Results 1 to 10 of about 29,398 (186)

Isoquercitrin induces melanogenesis in B16F10 melanoma cells and zebrafish via the p38 and PKA/CREB signaling pathways: an experimental study [PDF]

Journal of Yeungnam Medical Science
Background Isoquercitrin (IQ), a flavonoid with anticancer, antioxidant, anti-inflammatory, and antiallergic properties, exhibits dual effects on B16F10 melanoma cells by suppressing cell viability and inducing hyperpigmentation.
Jun Ha Lee, Ye Sol Ko, Young Seok Eom, Song Ja Kim   +3 more
doaj   +2 more sources

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis [PDF]

Advanced Science
The skin's unique thermosensitivity renders it exceptionally responsive to thermal perturbations, wherein heat stress exposure disrupts cutaneous homeostasis and activates pigmentary pathways.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
doaj   +2 more sources

Dual Modulatory Effects of Phytochemicals from Iris ×germanica L. var. florentina Dykes Rhizome Extract on Melanogenesis [PDF]

Molecules
Abnormal skin pigmentation can cause significant esthetic concerns and impact quality of life. As melanin determines pigmentation, melanogenesis is a key target to manage pigmentation disorders.
Sunghan Yim, Lisa Rozga, Steve Missler, Dmitri Sitnikov, Xiaozhong Liu, Sudhir Baswan   +5 more
doaj   +2 more sources

<i>Laetiporus sulphureus</i> Mycelial Extract Promotes Melanogenesis via p38 MAPK-Mediated Activation of β-Catenin/MITF and Rho Family Proteins in B16F10 Cells. [PDF]

J Microbiol Biotechnol
Park SJ, Choi HJ, Choi JW, Im GE, Park Y, Lee KT, Jeong JB.   +6 more
europepmc   +3 more sources

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

iScience, 2023
Summary: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that
Lan Zhang, Hongliang Zeng, Ling Jiang, Chuhan Fu, Yushan Zhang, Yibo Hu, Xiaolin Zhang, Lu Zhu, Fan Zhang, Jinhua Huang, Jing Chen, Qinghai Zeng   +11 more
doaj   +1 more source

DDX3 Upregulates Hydrogen Peroxide-Induced Melanogenesis in Sk-Mel-2 Human Melanoma Cells

Molecules, 2022
DDX3 is a DEAD-box RNA helicase with diverse biological functions through multicellular pathways. The objective of this study was to investigate the role of DDX3 in regulating melanogenesis by the exploring signaling pathways involved.
Sanung Eom, Shinhui Lee, Jiwon Lee, Hye Duck Yeom, Seong-Gene Lee, Junho Lee   +5 more
doaj   +1 more source

Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of Argania spinosa Leaves Extract

Molecules, 2022
Plant saponins are abundant and diverse natural products with a great potential for use in drug-discovery research. Here, we evaluated extracts of saponins-rich fractions of argan leaves and argan oil extraction byproducts (shell, pulp, press cake) for ...
Myra O. Villareal, Thanyanan Chaochaiphat, Rachida Makbal, Chemseddoha Gadhi, Hiroko Isoda   +4 more
doaj   +1 more source

Molecular Mechanisms of Anti-Melanogenic Gedunin Derived from Neem Tree (Azadirachta indica) Using B16F10 Mouse Melanoma Cells and Early-Stage Zebrafish

Plants, 2021
Melanogenesis represents a series of processes that produce melanin, a protective skin pigment (against ultraviolet rays), and determines human skin color. Chemicals reducing melanin production have always been in demand in the cosmetic market because of
Hwang-Ju Jeon, Kyeongnam Kim, Chaeeun Kim, Myoung-Jin Kim, Tae-Oh Kim, Sung-Eun Lee   +5 more
doaj   +1 more source

Spontaneous Formation of Melanin from Dopamine in the Presence of Iron

Antioxidants, 2020
Parkinson’s disease is associated with degeneration of neuromelanin (NM)-containing substantia nigra dopamine (DA) neurons and subsequent decreases in striatal DA transmission. Dopamine spontaneously forms a melanin through a process called melanogenesis.
David M. Hedges, Jordan T. Yorgason, Andrew W. Perez, Nathan D. Schilaty, Benjamin M. Williams, Richard K. Watt, Scott C. Steffensen   +6 more
doaj   +1 more source

The Function of Autophagy as a Regulator of Melanin Homeostasis

Cells, 2022
Melanosomes are melanocyte-specific organelles that protect cells from ultraviolet (UV)-induced deoxyribonucleic acid damage through the production and accumulation of melanin and are transferred from melanocytes to keratinocytes.
Ki Won Lee, Minju Kim, Si Hyeon Lee, Kwang Dong Kim   +3 more
doaj   +1 more source