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Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles.
Sulekha Kumari +3 more
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Mechanisms regulating melanogenesis* [PDF]
Skin pigmentation is an important human phenotypic trait whose regulation, in spite of recent advances, has not yet been fully understood. The pigment melanin is produced in melanosomes by melanocytes in a complex process called melanogenesis. The melanocyte interacts with endocrine, immune, inflammatory and central nervous systems, and its activity is
Videira, Inês Ferreira dos Santos +2 more
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Melanogenesis and Hypopigmentation
Melanocytes are highly specialized dendritic cells that synthesize and store melanin in subcellular organelles called melanosomes, before transfer to keratinocytes. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair and eyes.
Vinardell Martínez-Hidalgo, Ma. Pilar +2 more
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Fluoroquinolones cause phototoxic reactions, manifested as different types of skin lesions, including hyperpigmentation. The disturbances of melanogenesis indicate that fluoroquinolones may affect cellular processes in melanocytes.
Justyna Kowalska +5 more
doaj +1 more source
Perspective approaches on melanogenesis inhibition
Melanogenesis is a melanin-forming process responsible for protecting the skin against ultraviolet radiation damage. An excess production of melanin, however, may result in hyperpigmentation (darkening of the skin) to adverse dermatological effects ...
Aimi Syamima Abdul Manap +5 more
doaj +1 more source
Fermentation of rice grains requires diverse metabolic enzymes to be synchronously synthesized by the microbial community. Although many studies have used a metaproteomic approach to investigate the roles of microorganisms in improving the flavor of ...
Orrarat Sangkaew +3 more
doaj +1 more source
Paracrine regulation of melanogenesis [PDF]
Melanocytes are generally characterized by the basic ability of melanin synthesis and transfer to adjacent keratinocytes. This constitutes an individual skin phenotype and provides epidermal protection from various stimuli, such as ultraviolet irradiation, through a complex process called melanogenesis, which can be regulated by autocrine or paracrine ...
X.H. Yuan, Z.H. Jin
openaire +2 more sources
Effect of Phlorotannins Isolated From on Melanogenesis in Mouse B16 Melanoma Cells
Phlorotannins isolated from brown algae, such as Eisena bicyclis , have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease.
Yuki Ohno +4 more
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Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation
Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar +12 more
doaj +1 more source
Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood.
Chunxing Pan +11 more
doaj +1 more source

