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Mechanisms regulating melanogenesis* [PDF]
Anais Brasileiros de Dermatologia, 2013 Skin pigmentation is an important human phenotypic trait whose regulation, in spite of recent advances, has not yet been fully understood. The pigment melanin is produced in melanosomes by melanocytes in a complex process called melanogenesis. The melanocyte interacts with endocrine, immune, inflammatory and central nervous systems, and its activity is
Videira, Inês Ferreira dos Santos +2 more
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Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation
Cells, 2022 Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar +12 more
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Dynamics of Melanogenesis Intermediates.
Journal of Investigative Dermatology, 1993 The course of melanogenesis in (malignant) melanocytes is determined by several relatively independent metabolic processes such as tyrosine uptake and compartmentation, the activity of tyrosinase, and the capacity of melanosomes to produce and store melanin. There is experimental evidence that tyrosine is transported across the cell membrane with a Na(+
Pavel, Stanislav
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Melanogenesis and the Targeted Therapy of Melanoma
Biomolecules, 2022 Pigment production is a unique character of melanocytes. Numerous factors are linked with melanin production, including genetics, ultraviolet radiation (UVR) and inflammation.
Cang Li, Le Kuai, Rutao Cui, Xiao Miao
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Scientific ReportsAlthough previous studies have examined the signaling pathway involved in melanogenesis through which ultraviolet (UV) or α-melanocyte-stimulating hormones (α-MSH) stimuli act as key inducers to produce melanin at the stratum basal layer of the epidermis,
Dohyun Jeung +13 more
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Isoquercitrin induces melanogenesis in B16F10 melanoma cells and zebrafish via the p38 and PKA/CREB signaling pathways: an experimental study [PDF]
Journal of Yeungnam Medical ScienceBackground Isoquercitrin (IQ), a flavonoid with anticancer, antioxidant, anti-inflammatory, and antiallergic properties, exhibits dual effects on B16F10 melanoma cells by suppressing cell viability and inducing hyperpigmentation.
Jun Ha Lee +3 more
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Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis [PDF]
Advanced ScienceThe skin's unique thermosensitivity renders it exceptionally responsive to thermal perturbations, wherein heat stress exposure disrupts cutaneous homeostasis and activates pigmentary pathways.
Yushan Zhang +6 more
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Drug Design, Development and Therapy, 2019 Deng Zang,1,2 Chao Niu,1 Haji Akber Aisa1 1Key Laboratory of Plant Resources and Chemistry in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry ...
Zang D, Niu C, Niu C, Aisa HA
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Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves
Molecules, 2018 The individual parts of Morus alba L. including root bark, branches, leaves, and fruits are used as a cosmetic ingredient in many Asian countries. This study identified several anti-melanogenesis constituents in a 70% ethanol extract of M.
Hong Xu Li +7 more
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iScience, 2023 Summary: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that
Lan Zhang +11 more
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